Business Wire

Valbiotis Announces the Publication of the First Scientific Papers on TOTUM•63 in Three International Journals, Elucidating Its Multitarget Mode of Action

Share

Regulatory News:

Valbiotis (FR0013254851 – ALVAL, PEA / SME eligible), a Research and Development company committed to scientific innovation for preventing and combating metabolic diseases, announces the first publication of preclinical and clinical Phase I/II data on TOTUM•63 in three peer-reviewed international scientific journals: the American Journal of Physiology-Endocrinology and Metabolism, the International Journal of Obesity and Nutrients. These papers bring together a first set of results from the development of this active substance for the reduction of the risk of type 2 diabetes. They represent a first and comprehensive elucidation of mechanisms of action, to prepare for further scientific communications as part of a strategy of TOTUM•63, developed in collaboration with Nestlé Health Science as part of the global strategic partnership. This plan includes the publication of all TOTUM•63 preclinical and clinical results to accompany subsequent marketing of this active substance.

Pascal SIRVENT, Chief Scientific Officer, member of the Valbiotis Board of Directors, comments: ‘These three publications by leading journals constitute a major scientific recognition of our R&D work on TOTUM•63 for the prevention of type 2 diabetes. They represent a very powerful endorsement of the TOTUM•63 results, already presented at international congresses, on carbohydrate homeostasis and weight, on the pleiotropic mode of action of this active substance on several tissues, and on its safety of use. New preclinical data on the benefit of TOTUM•63 in combination with physical activity has also been published. This first publishing success kicks off our scientific promotion strategy for this program, which is being carried out alongside our partner Nestlé Health Science and will lead to the comprehensive publication of the results obtained with TOTUM•63. This strategy reflects our high scientific standards. But above all, it is a decisive factor for the successful marketing of TOTUM•63 throughout the world.’

Hans-Juergen WOERLE, Chief scientific and chief medical officer at Nestlé Health Science, states: ‘Comprehensive scientific publications for TOTUM•63 ensure high scientific validity of the quality of results for this active substance. This is instrumental for a health product, where often times a comprehensive understanding of mechanisms are lacking, and will pave the way for anticipated use of TOTUM•63 in prediabetes and blood glucose disorders. We are delighted with these first publications, working alongside the Valbiotis teams and its highly reputable academic partners.’

First three publications in leading international peer-reviewed journals

The three papers have been accepted and published in the following three journals:

  • The American Journal of Physiology, published since 1898 by the American Physiology Society, the main American scientific society dedicated to physiology and all its disciplines. 5-year Impact Factor: 4.209.
  • The International Journal of Obesity, published by the Nature group, one of the world's most respected scientific publishers. It promotes the study of obesity through a multidisciplinary approach. 5-year Impact Factor: 5.336.
  • Nutrients, a journal of the MDPI Group, a pioneer in online scientific publishing. It is supportedby a consortium of several national and international learned societies in the field of nutrition. 5-year Impact Factor: 5.089.

The research work on which these publications are based was carried out by the Valbiotis R&D platform and through close collaboration between the Company and its French and international academic partners. The University of Clermont Auvergne, the Clermont Auvergne Clinical Investigation Center (Centre d’investigation clinique Clermont Auvergne), La Rochelle University, Claude Bernard University in Lyon, INRA, INSERM, CNRS, Vanderbilt University in Nashville (USA) and Leiden University (Netherlands) are among the co-authors.

Citations:

- Chavanelle V et al.,Effects of TOTUM•63 on glucose homeostasis and post‐prandial glycemia: a translational study, American journal of Physiology – Endocrinology and metabolism, 2021.
journals.physiology.org/doi/abs/10.1152/ajpendo.00629.2020

- Van der Zandea H. et al., Effects of a novel polyphenol-rich plant extract on body composition, inflammation, insulin sensitivity and glucose homeostasis in obese mice, International Journal of Obesity, 2021.
www.nature.com/articles/s41366-021-00870-x

- Dupuit M. et al., The TOTUM•63 Supplement and High-Intensity Interval Training Combination Limits Weight Gain, Improves Glycemic Control, and Influences the Composition of Gut Mucosa-Associated Bacteria in Rats on a High Fat Diet, Nutrients, 2021.
www.mdpi.com/2072-6643/13/5/1569

About TOTUM•63
TOTUM•63 is a unique and patented combination of 5 plant extracts, with high potential to target the physiopathological mechanisms of Type 2 Diabetes.
TOTUM•63 has already been proven safe and effective in healthy human volunteers during a Phase I/II clinical study. The results of the international randomized, placebo-controlled Phase II study showed that TOTUM•63 reduced fasting and 2-hour blood sugar levels, two risk factors for Type 2 Diabetes, in prediabetics compared to placebo. In these subjects, who also had abdominal obesity, TOTUM•63 significantly reduced body weight and waist circumference.
TOTUM•63 benefits from intellectual property granted in the main markets worldwide: Europe (covering 39 countries), the United States, Russia, China, Japan, Mexico, Indonesia, Israel, South Africa, New-Zealand and national phases are underway in more than 10 countries including Brazil and Australia. The ability to produce TOTUM•63 industrially, in compliance to North American and European standards, has been validated. TOTUM•63 already has marketing authorizations related to its status in Europe.
In 2020, Valbiotis has signed a global and long-term partnership with Nestlé Health Science for the development and worldwide commercialization of TOTUM•63. This unique partnership in the field of Nutrition Health plans that TOTUM•63 will be put on the market by Nestlé Health Science at a global level, possibly before obtaining a health claim, depending on the areas. It will also provide funding for the latest development stages of TOTUM•63.

About Valbiotis
VALBIOTIS is a Research & Development company committed to scientific innovation preventing and combating metabolic diseases in response to unmet medical needs.
VALBIOTIS has adopted an innovative approach, aiming to revolutionize healthcare by developing a new class of health nutrition products designed to reduce the risk of major metabolic diseases, based on a multi-target approach enabled by the use of plant-based ingredients.
Its products are intended to be licensed to players in the health sector.
Created at the beginning of 2014 in La Rochelle, the Company has forged numerous partnerships with leading academic centers. The Company has established three sites in France: Périgny, La Rochelle (17) and Riom (63).
Valbiotis is a member of the "BPI Excellence" network and has been recognized as an "Innovative Company" by the BPI label. Valbiotis has also been awarded "Young Innovative Company" status and has received major financial support from the European Union for its research programs via the European Regional Development Fund (ERDF). VALBIOTIS is a PEA-SME eligible company.
For more information about VALBIOTIS, please visit: www.valbiotis.com.

Name: Valbiotis
ISIN code: FR0013254851
Mnemonic code: ALVAL
EnterNext© PEA-PME 150

This press release contains forward-looking statements about Valbiotis' objectives. Valbiotis considers that these projections are based on rational hypotheses and the information available to the company at the present time. However, in no way does this constitute a guarantee of future performance, and these projections may be reconsidered based on changes in economic conditions and financial markets, as well as a certain number of risks and uncertainties, including those described in the Valbiotis registration document, approved by the French Financial Markets Regulator (AMF) on 31 July 2020 (application number R 20-018). This document is available on the Company's website (www.valbiotis.com).
This press release, as well as the information contained herein, does not constitute an offer to sell or subscribe to, or a solicitation to purchase or subscribe to, Valbiotis' shares or securities in any country.

To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.

Contact information

Corporate communication / Valbiotis
Carole Rocher / Marc Delaunay
+33 5 46 28 62 58
media@valbiotis.com

Financial communication / Actifin
Stéphane Ruiz
+33 1 56 88 11 14
sruiz@actifin.fr

About Business Wire

Business Wire
Business Wire
24 Martin Lane
EC4R 0DR London

+44 20 7626 1982http://www.businesswire.co.uk

(c) 2018 Business Wire, Inc., All rights reserved.

Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.

Subscribe to releases from Business Wire

Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from Business Wire

Ambarella Expands Security AI Vision SoC Portfolio With Two New Families; Doubles Resolution to 32MP30 for 4K Multi-Imager Cameras With Advanced AI21.6.2021 11:00:00 CEST | Press release

Ambarella, Inc. (NASDAQ: AMBA), an AI vision silicon company, today announced the expansion of its AI vision SoC portfolio with the new CV5S and CV52S security families. Based on the CVflow® architecture and advanced 5nm process technology, the new SoCs support simultaneous 4K encoding and advanced AI processing in a single low-power design, which provides industry-leading edge AI SoC performance per watt. The CV5S family is ideal for security camera applications that require multiple sensors for 360-degree coverage, over a wide area and with a long range, such as outdoor city environments or large buildings. The CV52S family is designed for single-sensor security cameras with advanced AI performance that need to more clearly identify individuals or objects in a scene, including faces and license plate numbers over long distances, such as ITS traffic cameras. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20210621005178/en/ Am

Ezbob Introduces New SaaS Platform to Meet the Changing Landscape of Digital Banking21.6.2021 11:00:00 CEST | Press release

Ezbob Ltd., an innovator in customer acquisition technology for financial services, today announced the introduction of a new modular SaaS platform that addresses key trends in the sector. The company’s Ezbob Express™, focuses on three important needs: offering financial service providers the flexibility of filling gaps in their digital transformation strategies, enabling them to make more precise complex credit and risk decisions in real-time, and facilitating the growth of embedded finance. Ezbob’s new Express customer acquisition platform has a modular approach, enabling financial institutions with gaps in their digital channel to add the functionality needed to achieve a customised digital experience. The new modules include: UX & Process Design, Compliance & Authentication, Credit & Risk Decisioning and Product Recommender. Since its inception Ezbob has been providing digital onboarding services for many well-known financial institutions including Santander, NatWest, Metro Bank, P

Jardiance ® (empagliflozin) approved in Europe for the treatment of heart failure with reduced ejection fraction21.6.2021 10:36:00 CEST | Press release

The European Commission has granted marketing authorization for Jardiance® (empagliflozin) as a treatment for adults with symptomatic chronic heart failure with reduced ejection fraction (systolic heart failure), Boehringer Ingelheim and Eli Lilly and Company have announced.The extension of the indication follows a positive recommendation by the Committee for Medicinal Products for Human Use (CHMP) on 20 May 2021.2 This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20210621005298/en/ “Today’s approval provides an important new treatment option which can now help the millions of people in Europe living with symptomatic chronic heart failure with reduced ejection fraction,” said Faiez Zannad, M.D., Ph.D., EMPEROR Program clinical investigator and Emeritus Professor of Therapeutics at the University of Lorraine, France. “New treatment options such as empagliflozin can save lives and help people spend less time in the hospital and mor

SK Capital Reaches Agreement to Sell Niacet for $1,015m21.6.2021 10:00:00 CEST | Press release

An affiliate of funds advised by SK Capital Partners, LP (“SK Capital”) announced today that it reached agreement to sell Niacet Corp. (“Niacet”) to Kerry Group plc, the global taste and nutrition company, for $1,015m (€853m¹) on a cash-free, debt-free basis, subject to customary closing adjustments. Following the acquisition, Niacet will be integrated into Kerry’s global food protection and preservation platform. Jack Norris, Managing Director at SK Capital, said, “SK Capital is privileged to have partnered with Kelly Brannen and the entire Niacet team. We are proud and appreciative of Niacet’s accomplishments over the last four years leveraging the strong foundation the Brannen family built over many decades. We believe Niacet is well-positioned to continue this growth and flourish under Kerry’s ownership. We wish Kerry and all the employees of Niacet every success.” Kelly Brannen, CEO and significant minority owner of Niacet, commented, “We are proud of the rich heritage we have bui

ISAE-SUPAERO's "Collaborative Rover and Drone" Project, Facilitating the Exploration of the Moon21.6.2021 09:54:00 CEST | Press release

While Thomas Pesquet launched on April 22 as part of the Alpha mission, one of humanity's biggest challenges remains even further away than the ISS, 400,000 km from Earth: the establishment of a lunar base. But before being able to settle on the Moon in a prolonged way to exploit its resources or as a logistic support for future exploration missions further away, an exploration work is necessary. The use of autonomous robotic systems would allow mapping of dangerous or hard-to-reach areas from space, before eventually deploying infrastructure such as a spaceport or human habitation. Faced with this exploration challenge, the Space Advanced Concepts Laboratory (SaCLaB) of ISAE-SUPAERO in Toulouse and a team of students from the Institute are developing the Collaborative Rover and Drone (CoRoDro) project to study navigation and autonomous operations for space robotic systems. This scientific study is one of 12 university technology projects selected in 8 different countries as part of th

FXVIEW Goes Global, Sets up a Subsidiary in Saint Vincent and Grenadines21.6.2021 09:47:00 CEST | Press release

Fxview, Cyprus based forex and CFDs financial services company, announced today that it has set up an offshore subsidiary in St Vincent & The Grenadines. Until now, Fxview has been operating with its EU licenses from Cyprus. Charlgate SVG LLC, their locally incorporated arm will ensure the expansion of products and services on Fxview’s platforms. It will also allow them to offer regulated forex and CFDs trading services to traders around the globe. Fxview operates in Europe with its multiple European Licenses and is already an established brand in the EU market. Earlier this month, the company was acquired by a global FinTech leader Finvasia Group. “We anticipate that many more traders will join our platform where we plan to offer additional products and services like research & analysis, higher leverage, sophisticated trading tools, social trading, MAM / PAMM services, affiliate programs, loyalty reward programs and more,” said Rahul Bansal, Director of Charlgate SVG LLC. “We have bee

Ajay Kavan Joins KKR as a Senior Advisor in Europe21.6.2021 09:00:00 CEST | Press release

KKR, a leading global investment firm, today announces the appointment of Ajay Kavan as a Senior Advisor in Europe, effective immediately. Based in London, Mr. Kavan will support KKR’s pan-European investment activities in technology and digitally-enabled businesses and will advise KKR’s portfolio companies. In particular, he will focus on the consumer internet sector in eCommerce and direct-to-consumer offers, as well as companies undergoing major digital transformation programmes. Ajay most recently served as CEO of Matches Fashion, where he supported the business through the impact of the pandemic, strengthened the leadership team and improved customer experience, technology and operational performance. Prior to joining Matches he spent nine years in senior roles at Amazon including VP International Special Projects, VP Amazon Fresh International and VP UK Consumables. He was responsible for launching Amazon Fresh across Europe and Asia, developing strategic partnerships with retail