Business Wire

Spinal Cord Stimulation Delivers Improved Arm Function

Share

ONWARD Medical N.V. (Euronext: ONWD), the medical technology company creating innovative therapies to restore movement, independence, and health in people with spinal cord injury, today announces a Nature Neuroscience publication showing the potential for ONWARD’s ARCIM Therapy to restore movement and function in hands and arms after spinal cord injury.

Regaining hand and arm function is the highest priority for many people with cervical spinal cord injury. Even mild functional deficits in hand and arm function lead to significantly reduced independence and quality of life. It has historically been challenging to develop new therapies for hand and arm function because their movements are complex and multidimensional. Researchers in today’s Nature Neuroscience publication investigated a potentially more effective approach to improving motor control of the upper limbs after spinal cord injury – an implantable neurostimulation system that modulates the spinal cord region involved in controlling hand and arm function. This preclinical data showed that precise electrical stimulation targeting relevant spinal cord segments enhanced muscle activation and strength, and facilitated more efficient hand and arm movements.

“We are preparing to launch our transcutaneous ARCEX Therapy to restore hand and arm function in 2023,” said Dave Marver, CEO of ONWARD. ”The findings from this Nature Neuroscience publication suggest there may also be a role for implanted ARCIM Therapy to help people with spinal cord injury regain arm and hand function. Indeed, the greater precision and 24/7 availability of implanted ARCIM Therapy may offer meaningful support for activities of daily living.”

“Small improvements in hand and arm function offer large benefits in independence and quality of life. Current approaches such as functional electrical stimulation (FES) induce fatigue and fail to sustain the three-dimensional movements required for activities of daily life”, said Grégoire Courtine, professor at EPFL and co-author of the Nature Neuroscience paper. “We look forward to studying this approach in humans within the next several months and working with ONWARD to potentially commercialize this important therapy.”

As part of its suite of intellectual property agreements with EPFL, ONWARD has the rights to develop and commercialize cervical spinal cord stimulation therapy to improve hand and arm function in people with spinal cord injury.

The publication features preclinical research performed by neuroscientists at EPFL, University of Fribourg, and University of Pittsburgh. The research initiative was sponsored by the Wyss Foundation, ONWARD, the Bertarelli Foundation, the Swiss National Science Foundation, and the European Union’s Horizon 2020 program.

To learn more about ONWARD’s ARC Therapy and the company’s vision to restore movement, independence, and health in people with spinal cord injury, please visit ONWD.com.

About ONWARD

ONWARD is a medical technology company creating innovative therapies to restore movement, independence, and health in people with spinal cord injuries. ONWARD’s work builds on more than a decade of basic science and preclinical research conducted at the world’s leading neuroscience laboratories. ONWARD’s ARC Therapy, which can be delivered by implantable (ARCIM) or external (ARCEX) systems, is designed to deliver targeted, programmed spinal-cord stimulation to restore movement and other functions in people with spinal cord injury, ultimately improving their quality of life. ONWARD has received three Breakthrough Device Designations from the FDA encompassing both ARCIM and ARCEX. The company’s first FDA pivotal trial, called Up-LIFT, completed enrollment in December 2021 with 65 subjects worldwide. The company completed its first-in-human use of its ARCIM neurostimulator in May 2022.

ONWARD is headquartered at the High Tech Campus in Eindhoven, the Netherlands. It maintains an office in Lausanne, Switzerland, and has a growing U.S. presence in Boston, Massachusetts, USA. For additional information about the company, please visit ONWD.com. To access our 2022 Financial Calendar, please visit IR.ONWD.com.

Disclaimer

Certain statements, beliefs and opinions in this press release are forward-looking, which reflect the Company or, as appropriate, the Company directors’ current expectations and projections about future events. By their nature, forward-looking statements involve a number of risks, uncertainties and assumptions that could cause actual results or events to differ materially from those expressed or implied by the forward-looking statements. These risks, uncertainties and assumptions could adversely affect the outcome and financial effects of the plans and events described herein. A multitude of factors including, but not limited to, changes in demand, competition and technology, can cause actual events, performance or results to differ significantly from any anticipated development. Forward looking statements contained in this press release regarding past trends or activities should not be taken as a representation that such trends or activities will continue in the future. As a result, the Company expressly disclaims any obligation or undertaking to release any update or revisions to any forward-looking statements in this press release as a result of any change in expectations or any change in events, conditions, assumptions or circumstances on which these forward-looking statements are based. Neither the Company nor its advisers or representatives nor any of its subsidiary undertakings or any such person’s officers or employees guarantees that the assumptions underlying such forward-looking statements are free from errors nor does either accept any responsibility for the future accuracy of the forward-looking statements contained in this press release or the actual occurrence of the forecasted developments. You should not place undue reliance on forward-looking statements, which speak only as of the date of this press release.

To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.

Contact information

For Company Enquiries:
info@onwd.com

For Media Enquiries:
Laurie Doyle
media@onwd.com
+1 339 832 0752

For Investor Enquiries:
investors@onwd.com

About Business Wire

Business Wire
Business Wire
24 Martin Lane
EC4R 0DR London

+44 20 7626 1982http://www.businesswire.co.uk

(c) 2018 Business Wire, Inc., All rights reserved.

Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.

Subscribe to releases from Business Wire

Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from Business Wire

NFT Naruto Museum Foundation: Exclusive Agreement Signed for Metaverse and NFT Rights to Michael Jackson Wonder World Toys10.8.2022 12:00:00 CEST | Press release

NFT Naruto Art Museum (located in Naruto City, Tokushima Prefecture; CEO: Taisei Yamaguchi; hereinafter "NFT Naruto Art Museum") and The Jackson Family Foundation Japan (located in Minato-ku, Tokyo; President: Kenji Koga; hereinafter "JFFJ") have signed an exclusive agreement for the NFT and Metaverse rights to MJWWT "Michael Jackson Wonder World Toys" for the MUSEUM DAO. NFT Naruto Museum of Art reopened on March 1, 2022 with a name change from "Naruto Galle Forest Museum" to "NFT Naruto Museum of Art" as the first museum in Japan to handle "NFT". It is the first NFT museum in Japan to specialize in the publication, examination, sale (primary sales), and distribution (secondary sales) of NFTs related to art and artwork. The Jackson Family Foundation Japan is a charitable non-profit organization as the official Japanese branch of the Jackson Family Foundation, established by the parents of the late Michael Jackson. The MJWWT project is a world where Michael Jackson himself drew a sketc

Celebrities and Young Activists join PUMA’s Conference of the People to find Solutions for Industry’s Sustainability Challenges10.8.2022 10:09:00 CEST | Press release

Sports company PUMA will be joined by celebrities and young activists during its one-day “Conference of the People” in London on September 6, which will discuss solutions for some of the fashion industry’s most pressing sustainability challenges, with a special focus on Gen Z. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20220810005354/en/ Sports company PUMA will discuss solutions for some of the fashion industry’s most pressing sustainability challenges such as waste, materials and climate change at a global event called "Conference of the People" in September. Actress, model and activist Cara Delevingne will host the event alongside PUMA CEO Bjørn Gulden and PUMA CSO Anne-Laure Descours. (Photo: Business Wire) Joining Actress, Model and Activist Cara Delevingne, Writer, Director and Broadcaster Reggie Yates will be guiding the audience through the event. The panel discussions on the day will be led by TV Presenter and Par

New IT Audit Fundamentals Certificate from ISACA Helps Professionals Launch Careers10.8.2022 08:30:00 CEST | Press release

Those seeking a strong foundation in IT audit knowledge and hands-on experience to set themselves apart as they seek audit jobs can now earn the new ISACA IT Audit Fundamentals Certificate from ISACA, the global professional association for digital trust professionals. ISACA’s IT Audit Fundamentals Certificate program offers valuable knowledge and performance-based hybrid learning that will empower early professionals and those looking to change careers to IT audit to gain insight into the principles of IT audit and the opportunity to build a foundation of knowledge and skill to be a successful IT auditor. “ISACA is a career partner for professionals at every level of their careers, including those just getting started or those looking to switch careers,” said Shannon Donahue, Senior Vice President of Publishing at ISACA. “IT audit is truly a rewarding career field with incredible opportunity. But there are currently few resources available that prepare rising professionals or career c

Smiths Detection equips Leonardo di Vinci International Airport in Rome with advanced carry-on baggage screening technology10.8.2022 08:00:00 CEST | Press release

Smiths Detection, a global leader in threat detection and security inspection technologies, announces that it has begun installing 30 HI-SCAN 6040 CTiX carry-on baggage screening systems at Leonardo di Vinci International Airport in Rome. The installation of this world-leading technology reflects the airport’s high standards for passenger service excellence and process automation, having recently been awarded the ACI Best Airport in Europe for the fourth time in the last five years. Smiths Detection’s HI-SCAN 6040 CTiX is a computed tomography (CT) X-ray scanner producing high-resolution volumetric 3D images for quicker and deeper baggage assessment and low false-alarm rates. The scanners allow for electronics and liquids to remain in bags, speeding up passenger screening and reducing touchpoints. The combination of the CT X-ray scanners, alongside 45 already supplied Smiths Detection IONSCAN 600 trace detectors, will further improve security and operational efficiency. The IONSCAN 600

Lenovo Group: First Quarter Results 2022/2310.8.2022 01:41:00 CEST | Press release

Lenovo Group (HKSE: 992) (ADR: LNVGY) today announced strong first quarter results for the Group, improving both revenue and profitability for the ninth consecutive quarter. First quarter net income grew 11% year-on-year to US$516 million and 35% year-on-year to $556 million on a non-HKFRS [1] basis. Revenue grew to US$17 billion, up 5% year-on-year in constant currency. The Group saw revenue from non-PC businesses reach 37%, demonstrating its services-led transformation strategy and persistent investments in diversifying the business have paid off and are driving future growth opportunities. These new growth engines of solutions and services, infrastructure solutions, and mobile businesses all grew revenue by double digits year-on-year – contributing to both topline growth and Lenovo’s wider commitment to double profitability in the midterm. The Group remains committed to doubling investments in Research and Development (R&D) and grew R&D spending 10% year on year and increased R&D he