Business Wire

Researchers Harness the Power of Masimo Root ® ’s Advanced Multimodal Monitoring Capabilities to Study the Impact of Different Ventilatory Strategies on Brain Oxygenation During Thoracoscopic Surgery

Share

Masimo (NASDAQ: MASI) today announced the findings of a prospective, single-blinded, randomized controlled study published in the Journal of Anesthesia & Intensive Care Medicine in which Dr. Mona Mohamed Mogahed and colleagues at Tanta University in Tanta, Egypt and The King Fahd General Hospital in Jeddah, Saudi Arabia, sought to evaluate the impact of varying ventilation strategies on the cerebral oxygenation of patients undergoing video-assisted thoracoscopic surgery (VATS). To monitor the variety of physiological parameters needed to undertake such an evaluation, they turned to the multi-modal Masimo Root® patient monitoring and connectivity platform, which is designed to allow clinicians to streamline their ability to keep track of numerous modalities, simultaneously, using a single, intuitive monitor. The technologies involved included O3® regional oximetry, capnography with NomoLine® sampling lines, SedLine® brain function monitoring, and multiple rainbow® Pulse CO-Oximetry measurements. Using Root and Masimo monitoring technologies, the researchers were able to determine that maintaining higher end-tidal carbon dioxide (EtCO2) improved baseline regional cerebral oxygenation (rSO2), with impacts on early postoperative cognitive function that included improvements in Aldrete scores and mini mental status exam (MMSE) scores.1

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230122005047/en/

To view this piece of content from mms.businesswire.com, please give your consent at the top of this page.

Masimo Root® (Graphic: Business Wire)

Noting the increased risk of hypoxemia during one-lung ventilation (OLV) as part of VATS, which can lead to postoperative neurocognitive dysfunctions, the authors hypothesized that increasing EtCO2 could be a “convenient and powerful” way to manage cerebral desaturation during the surgery. They enrolled 70 patients, ages 18-65, undergoing elective VATS requiring OLV, between September 2021 and September 2022 at The King Fahd General Hospital, Jeddah. All patients were operated on by the same surgical team. The patients were randomly divided into two groups: in the first, EtCO2 was maintained at 32-38 mmHg (group I) and in the second, at 39-45 mmHg (group II). During the procedure, monitored parameters included oxygen saturation (Masimo SET® SpO2), heart rate (HR), and noninvasive hemoglobin (Masimo SpHb®) via an RD rainbow SET® fingertip sensor; EtCO2 via capnometer and NomoLine sampling line; noninvasive blood pressure (NIBP), body temperature, and rSO2 via O3 near-infrared spectroscopy (NIRS) sensors monitoring both brain hemispheres; and Masimo Patient State Index (PSi™), a processed EEG parameter used to help clinicians maintain appropriate sedation, via SedLine. Outcomes included Aldrete scores and MMSE scores assessed at 3 and 24 hours after surgery.

The researchers found that the percentage of change in rSO2 differed significantly between groups (p < 0.05), on both sides of the brain, with the higher values, over time, in Group II, in direct relation with the higher EtCO2 maintained in that group. In the right hemisphere, the difference became significant at the fourth time interval [T4] at which rSO2 was recorded, p = 0.0012, and maintained significance for the remainder of surgery [T4-T13], p < 0.001. In the left hemisphere, the difference became significant at T2, p = 0.09, and remained significant [T3-13], p < 0.001. Aldrete scores were significantly higher in Group II upon arrival at the post-anesthesia care unit (PACU) (p = 0.013) and 15 minutes after arrival (p = 0.03), then became comparable. MMSE scores were significantly higher in Group II 3 hours after surgery (p = 0.0009), but not at 24 hours after surgery.

The researchers concluded, “Adjusting the ventilator parameters to develop EtCO2 of 39-45 mmHg improved cerebral oxygenation more than EtCO2 of 32-38 mmHg, that play[s] a protective role in the brain, causing significant impact on the early postoperative cognitive function in patients with OLV undergoing VATS.” Regarding the use of Masimo Root and associated monitoring technologies, they noted that they “preferred using it as it can display several clinical measurements [at] the same time, such as HR, BP, temperature, SpO2, EtCO2, PSi, and rSO2.”

@Masimo | #Masimo

About Masimo

Masimo (NASDAQ: MASI) is a global medical technology company that develops and produces a wide array of industry-leading monitoring technologies, including innovative measurements, sensors, patient monitors, and automation and connectivity solutions. In addition, Masimo Consumer Audio is home to eight legendary audio brands, including Bowers & Wilkins, Denon, Marantz, and Polk Audio. Our mission is to improve life, improve patient outcomes, and reduce the cost of care. Masimo SET® Measure-through Motion and Low Perfusion™ pulse oximetry, introduced in 1995, has been shown in over 100 independent and objective studies to outperform other pulse oximetry technologies.2 Masimo SET® has also been shown to help clinicians reduce severe retinopathy of prematurity in neonates,3 improve CCHD screening in newborns,4 and, when used for continuous monitoring with Masimo Patient SafetyNet™ in post-surgical wards, reduce rapid response team activations, ICU transfers, and costs.5-8 Masimo SET® is estimated to be used on more than 200 million patients in leading hospitals and other healthcare settings around the world,9 and is the primary pulse oximetry at 9 of the top 10 hospitals as ranked in the 2022-23 U.S. News and World Report Best Hospitals Honor Roll.10 In 2005, Masimo introduced rainbow® Pulse CO-Oximetry technology, allowing noninvasive and continuous monitoring of blood constituents that previously could only be measured invasively, including total hemoglobin (SpHb®), oxygen content (SpOC™), carboxyhemoglobin (SpCO®), methemoglobin (SpMet®), Pleth Variability Index (PVi®), RPVi™ (rainbow® PVi), and Oxygen Reserve Index (ORi™). In 2013, Masimo introduced the Root® Patient Monitoring and Connectivity Platform, built from the ground up to be as flexible and expandable as possible to facilitate the addition of other Masimo and third-party monitoring technologies; key Masimo additions include Next Generation SedLine® Brain Function Monitoring, O3® Regional Oximetry, and ISA™ Capnography with NomoLine® sampling lines. Masimo’s family of continuous and spot-check monitoring Pulse CO-Oximeters® includes devices designed for use in a variety of clinical and non-clinical scenarios, including tetherless, wearable technology, such as Radius-7®, Radius PPG®, and Radius VSM™, portable devices like Rad-67®, fingertip pulse oximeters like MightySat® Rx, and devices available for use both in the hospital and at home, such as Rad-97®. Masimo hospital and home automation and connectivity solutions are centered around the Masimo Hospital Automation™ platform, and include Iris® Gateway, iSirona™, Patient SafetyNet, Replica®, Halo ION®, UniView®, UniView :60™, and Masimo SafetyNet®. Its growing portfolio of health and wellness solutions includes Radius Tº® and the Masimo W1™ watch. Additional information about Masimo and its products may be found at www.masimo.com. Published clinical studies on Masimo products can be found at www.masimo.com/evidence/featured-studies/feature/.

ORi, RPVi, and Radius VSM have not received FDA 510(k) clearance and are not available for sale in the United States. The use of the trademark Patient SafetyNet is under license from University HealthSystem Consortium.

References

  1. Mogahed MM, Alnoamani TS, Elkahwagy MS. The Ventilatory Influence on Cerebral Oxygenation in Patients Undergoing Video Assisted Thoracoscopic Surgery. J Anest & Inten Care Med. 12(3). December 2022. DOI: 10.19080/JAICM.202212.555837.
  2. Published clinical studies on pulse oximetry and the benefits of Masimo SET® can be found on our website at http://www.masimo.com. Comparative studies include independent and objective studies which are comprised of abstracts presented at scientific meetings and peer-reviewed journal articles.
  3. Castillo A et al. Prevention of Retinopathy of Prematurity in Preterm Infants through Changes in Clinical Practice and SpO2 Technology. Acta Paediatr. 2011 Feb;100(2):188-92.
  4. de-Wahl Granelli A et al. Impact of pulse oximetry screening on the detection of duct dependent congenital heart disease: a Swedish prospective screening study in 39,821 newborns. BMJ. 2009;Jan 8;338.
  5. Taenzer A et al. Impact of pulse oximetry surveillance on rescue events and intensive care unit transfers: a before-and-after concurrence study. Anesthesiology. 2010:112(2):282-287.
  6. Taenzer A et al. Postoperative Monitoring – The Dartmouth Experience. Anesthesia Patient Safety Foundation Newsletter. Spring-Summer 2012.
  7. McGrath S et al. Surveillance Monitoring Management for General Care Units: Strategy, Design, and Implementation. The Joint Commission Journal on Quality and Patient Safety. 2016 Jul;42(7):293-302.
  8. McGrath S et al. Inpatient Respiratory Arrest Associated With Sedative and Analgesic Medications: Impact of Continuous Monitoring on Patient Mortality and Severe Morbidity. J Patient Saf. 2020 14 Mar. DOI: 10.1097/PTS.0000000000000696.
  9. Estimate: Masimo data on file.
  10. http://health.usnews.com/health-care/best-hospitals/articles/best-hospitals-honor-roll-and-overview.

Forward-Looking Statements

This press release includes forward-looking statements as defined in Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, in connection with the Private Securities Litigation Reform Act of 1995. These forward-looking statements include, among others, statements regarding the potential effectiveness of Masimo Root®, O3®, NomoLine®, SedLine®, rainbow®, RD rainbow SET®, SpHb®, SET®, and PSi™. These forward-looking statements are based on current expectations about future events affecting us and are subject to risks and uncertainties, all of which are difficult to predict and many of which are beyond our control and could cause our actual results to differ materially and adversely from those expressed in our forward-looking statements as a result of various risk factors, including, but not limited to: risks related to our assumptions regarding the repeatability of clinical results; risks related to our belief that Masimo's unique noninvasive measurement technologies, including Masimo Root, O3, NomoLine, SedLine, rainbow®, RD rainbow SET, SpHb, SET®, and PSi, contribute to positive clinical outcomes and patient safety; risks that the researchers’ conclusions and findings may be inaccurate; risks related to our belief that Masimo noninvasive medical breakthroughs provide cost-effective solutions and unique advantages; risks related to COVID-19; as well as other factors discussed in the "Risk Factors" section of our most recent reports filed with the Securities and Exchange Commission ("SEC"), which may be obtained for free at the SEC's website at www.sec.gov. Although we believe that the expectations reflected in our forward-looking statements are reasonable, we do not know whether our expectations will prove correct. All forward-looking statements included in this press release are expressly qualified in their entirety by the foregoing cautionary statements. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of today's date. We do not undertake any obligation to update, amend or clarify these statements or the "Risk Factors" contained in our most recent reports filed with the SEC, whether as a result of new information, future events or otherwise, except as may be required under the applicable securities laws.

To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.

Contact information

Media Contact:
Masimo
Evan Lamb
949-396-3376
elamb@masimo.com

About Business Wire

Business Wire
Business Wire
24 Martin Lane
EC4R 0DR London

+44 20 7626 1982http://www.businesswire.co.uk

(c) 2018 Business Wire, Inc., All rights reserved.

Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.

Subscribe to releases from Business Wire

Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from Business Wire

Taulia Signs Memorandum of Understanding With Aramco to Explore Supplier Financing Solutions6.2.2023 11:45:00 CET | Press release

Taulia, a leading provider of working capital management solutions, today announces it has signed a Memorandum of Understanding (MoU) with Aramco, one of the world's leading integrated energy and chemicals companies, to discuss Taulia providing supplier financing solutions. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230206005330/en/ As part of its In-Kingdom Total Value Add (iktva) program, which strives to accelerate digital transformation efforts domestically, Aramco recently signed over 100 agreements to help advance a diverse, sustainable and globally competitive industrial ecosystem (please see here for further details). Taulia is undertaking the program in collaboration with J.P. Morgan and Manafa Capital. Cedric Bru, CEO of Taulia, comments: “Through this program, we are paving the way for thousands of businesses worldwide to access affordable financing options and manage their liquidity as they continue to naviga

Ambassador Carlos dos Santos appointed as Executive Chairman of Compass Group Holdings.6.2.2023 10:49:00 CET | Press release

Compass Group Holdings, a leading Energy Project Management, and Integrated Services company operating in East Africa, and headquartered in Maputo, Mozambique, is delighted to announce the appointment of Ambassador Carlos dos Santos to the Board as Executive Chairman with immediate effect. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230206005124/en/ Ambassador Carlos dos Santos appointed as Executive Chairman of Compass Group Holdings. (Photo: Business Wire) Ambassador Carlos dos Santos is a career Diplomat with distinctive business experience and most recently served as The Ambassador of Mozambique to the United States and High Commissioner for Canada (2015-2022). Prior to this prominent role, his extensive and renowned career included serving as the High Commissioner for the United Kingdom, Ambassador to Ireland and Governor at the Commonwealth Board of Governors (2011-2015), and Ambassador of Mozambique to Germany, Aus

SYNTAGMA CAPITAL enters into exclusive negotiations to acquire Nexans’ LAN/data center (“LAN/DC”) and Telecom /Fibre (“FTTx”) division.6.2.2023 08:30:00 CET | Press release

Syntagma Capital today announces that it has entered into exclusive negotiations with Nexans SA to acquire its LAN/data center (“LAN/DC”) and Telecom /Fibre (“FTTx”) division. The business designs, manufactures, and distributes smart connectivity solutions based on optical fibre and copper technologies to data centers, smart buildings, and telecom operators. The business is headquartered in Paris, France and employs ca. 680 people across its 8 sites located in France, Belgium, Germany, Greece, Morocco and China, and it generated ca. €200m in revenues across 100+ countries. The proposed transaction, which is subject to the fulfillment of customary closing conditions, including the information and consultation of works councils and other regulatory approvals, is expected to be completed by the end of the first half of 2023. “We are pleased to partner with management to continue to grow the business. Providing the backbone for data management is an exciting prospect. Despite a challenging

Greenergy Data Centers Bring Sustainable Data Center Services to the Baltics with Juniper Networks6.2.2023 08:00:00 CET | Press release

Juniper Networks (NYSE:JNPR), a leader in secure, AI-driven networks, today announced that Greenergy Data Centers (GDC), the largest and most energy-efficient data center company in the Baltics, has deployed Juniper’s cloud-ready data center and AI-driven enterprise solutions to support its business and data center operations. GDC is the first and only large-scale data center in the Baltics, offering enterprises, government agencies and managed service providers a place to safely store their mission-critical data while minimizing their environmental footprint. The GDC data center is a 14,500-square-meter, 31.5-megawatt facility. Multiple levels of physical security keep the premises secure. Redundant power and digital infrastructure systems support highly reliable operations. Renewable energy sources and the Nordic climate lower cooling-related power consumption in the data center. Residual heat generated by equipment is used to warm GDC’s offices, and it also has the technical capacit

Opengear Launches CM8100 10G Product Family to Enable Smart Out-of-Band for Hyperscalers6.2.2023 08:00:00 CET | Press release

Opengear, a Digi International company (NASDAQ, DGII, www.digi.com/) and provider of secure and SmartOut-of-Bandmanagement solutions, today announced the expansion of its CM8100family with the launch of two new 10GbE models, CM8196-10G and CM8148-10G. These new offerings enable the deployment of Smart Out-of-Band management at scale while reducing integration efforts and maintenance overhead. Like the rest of the CM8100 family, the new products ensure resilient remote access with enhanced security and automation. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230206005023/en/ Opengear CM8100-10G with Lighthouse (Photo: Business Wire) Some of the key features and benefits of these CM8100-10G models include: Greater Efficiency: Customers can manage dense environments efficiently, connecting up to 96 serial devices. Open Architecture: A REST API supports automation tools, Docker, and Python scripting. Enhanced Security: Hardwar