Business Wire

Exscientia Business Update for Second Quarter and First Half 2022

Share

Exscientia plc (Nasdaq: EXAI)

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20220817005681/en/

Recent developments in the Company’s pipeline, collaborations, and operations, as well as financial results for the second quarter and first half 2022, are summarised below. In addition, Exscientia will host a conference call Thursday, August 18 at 1:30 p.m. BST / 8:30 a.m. ET to provide an overview of the company’s pipeline and corporate strategy.

“In the first half of 2022, we delivered on major new and existing collaborations, advanced our pipeline programmes, and marked the 10-year anniversary of Exscientia’s founding. Over the past decade, we’ve pioneered an AI-driven approach to modernising drug discovery and development, and it was fitting that this quarter we also announced topline data from our EXS-21546 programme, one of the first AI-designed molecules to enter clinical trials,” said Andrew Hopkins, D.Phil., Exscientia's founder and Chief Executive Officer. “With over $730 million in cash, we believe we are in a strong position to deliver across our portfolio of drug projects for the long-term. Our strategy creates an agile interplay between our internal pipeline and partnered programmes, enabling us to move candidates between the two depending on the best fit for Exscientia and our partners, as well as how we can best impact the probability of success for patients.”

Recent Highlights

Progress across internal and partnered pipeline, leveraging the Company's precision medicine platform, as well as key components of Exscientia's technology and operations.

Internal pipeline

Wholly, majority and co-owned programmes focused on areas in which Exscientia believes it can improve the probability of success, including precision oncology

  • Following topline data in June, the Company remains on track to initiate a Phase 1b/2 study of EXS-21546 (majority owned with Evotec) in the second half of 2022
    • Phase 1b/2 study will be optimised with simulation-guided clinical trial design principles as well as leverage Exscientia's precision medicine platform to maximise potential impact to the most relevant patients
  • GTAEXS-617 (co-owned with GT Apeiron) CTA submission expected by year-end 2022
    • CTA and IND-enabling studies are ongoing, including translational work to support planned clinical trials expected to start in the first half of 2023

Partnered programmes

Utilising a scalable end-to-end platform to advance a broad pipeline, while also generating significant cash inflows to support advancements

  • First two targets identified in new Sanofi collaboration for oncology and inflammation & immunity, respectively
  • First precision medicine project initiated; focused on patient enrichment for a Sanofi biologic in oncology
  • Advancing Bristol Myers Squibb (BMS) collaboration with continued progress across both BMS1 and BMS2 collaborations
  • Following the achievement of recent successful drug discovery milestone, Exscientia and Bayer have mutually agreed to end collaboration; Exscientia will retain optionality to develop one of the two targets pursued under the collaboration
    • The Bayer agreement was the last Exscientia partnership based on AI-only design services, which included lower economics and reduced operational involvement in comparison with more recent partnerships
    • This update aligns with Company strategy to increasingly focus on programmes where Exscientia’s AI design, experimental biology and precision medicine platforms can be integrated

Recent clinical progress highlights ability of the Company’s advanced, AI-based platform to create novel molecules with high level of translatability to human biology

  • Announced topline data from EXS-21546 Phase 1a healthy volunteer study in June 2022
    • The study demonstrated that observed human pharmacokinetics for EXS-21546 were in line with what had been designed for and predicted in preclinical modelling, supporting a twice-daily (BID) dose for continuous A2A receptor inhibition over a dosing interval
    • EXS-21546 signalled inhibition of A2A receptor was sustained over the BID dosing period, demonstrating a level of lasting target engagement
    • EXS-21546 was well-tolerated with no CNS adverse events reported in the SAD portion at all doses (30mg, 90mg, 250mg, 400mg) and in the MAD portion at 150mg BID

Exscientia's approach allows for significant cash inflows to drive the business

  • $111.0 million cash flow from collaborations in second quarter 2022, including $100.0 million from Sanofi, ending the first half 2022 with $732.0 million in cash, cash equivalents and short-term bank deposits
    • Includes constant currency mark-to-market foreign exchange impact of negative 8%
    • During the quarter, Exscientia recognised realised foreign exchange gains net of forward contract settlements of $14.0 million. The Company holds its deposits in both GBP and USD intended to match expected cash needs while limiting the impact of exchange rate fluctuations
  • Second quarter 2022 net positive cash inflows from operations of $72.9 million

Expanded leadership team in critical growth areas

  • Eileen Jennings-Brown joined as Exscientia's Chief Information Officer, reporting to Garry Pairaudeau, Chief Technology Officer, and responsible for overseeing IT and DevOps. Ms. Jennings-Brown brings more than 25 years of experience across IT roles, including most recently heading technology for the Wellcome Trust.
  • Charlotte Deane, Ph.D., Chief Scientist of Biologics AI, who joined Exscientia in January 2022, was awarded an appointment to the Most Excellent Order of the British Empire (MBE) for leading the UK Research and Innovation's rapid response call for projects addressing issues arising from the pandemic.

Select peer-reviewed publications and scientific meeting presentations during the quarter

  • Coverage Score: A Model Agnostic Method to Efficiently Explore Chemical Space,” was published in the Journal of Chemical Information and Modeling in July 2022. This advancement in active learning allows more efficient exploration of chemical space, potentially leading to increased diversity of candidates, faster model improvement and shorter time to candidate identification
  • Surface Plasmon Resonance Screening to Identify Active and Selective Adenosine Receptor Binding Fragments,” a study which further validates Exscientia's innovative biosensor approach to screening wildtype GPCR targets to advance drug discovery, was published in the ACS Medicinal Chemistry Letters in June 2022
  • Three posters presented at the AACR Annual Meeting in April, highlighting Exscientia’s human tissue precision medicine platform, including potential benefits of Exscientia’s AI-driven design to overcome known issues such as potency, toxicity and selectivity and improve patient outcomes

Investor call and webcast information

Exscientia will host a conference call on Thursday, August 18 at 1:30 p.m. BST / 8:30 a.m. ET. A webcast of the live call can be accessed by visiting the “Investors and Media” section of the Company’s website at investors.exscientia.ai. Alternatively, the live conference call can be accessed by dialling +1 (888) 330 3292 (U.S.), +44 203 433 3846 (U.K.), +1 (646) 960 0857 (International) and entering the conference ID: 8333895. A replay will be available for 90 days under "Events and Presentations” in the “Investors and Media” section of the Exscientia website.

Second quarter and first half 2022 financial results

For the convenience of the reader, the Company has translated pound sterling amounts to U.S. dollars at the rate of £1.000 to $1.2162, which was the noon buying rate of the Federal Reserve Bank of New York on June 30, 2022.

Revenue: Recognised revenue for the three and six months ended June 30, 2022, was $8.7 million and $17.2 million respectively, representing an increase of $8.3 million and $10.4 million compared to the three and six months ended June 30, 2021, primarily due to delivery on an increased number of projects across our second collaboration with BMS, revenues generated from the extension of the BMS agreement to leverage Exscientia's precision medicine platform, and recognition of remaining revenues following the termination of the Bayer agreement.

R&D and cost of drug discovery: Due to various collaboration structures, expenditure incurred in relation to research and development activities may be recognised within one of several financial statement captions. The tables below show how these expenses are separated across the accounting categories.

Three months ended June 30, 2022 ($ millions):

COGS 

R&D 

Share of JV 
loss 

Total 

Partnered Programmes 

10.9 

– 

– 

10.9 

Internal Pipeline and Technology Development 

– 

40.2 

0.3 

40.5 

Total 

10.9 

40.2 

0.3 

51.4 

Six months ended June 30, 2022 ($ millions):

COGS 

R&D 

Share of JV 
loss 

Total 

Partnered Programmes 

17.7 

– 

– 

17.7 

Internal Pipeline and Technology Development 

– 

68.8 

0.7 

69.5 

Total 

17.7 

68.8 

0.7 

87.2 

Research and development expenses: R&D expenses for the three and six months ended June 30, 2022, were $40.2 million and $68.8 million respectively, as compared to $9.9 million and $15.1 million for the same period ended June 30, 2021. The increase in research and development expenses was in part due to the growth of Exscientia's internal and co-owned portfolio, in addition to increased headcount and other costs associated with the Company's continued technology investments. Share-based compensation accounted for $9.1 million and $12.1 million for the quarter and half year ended June 30, 2022, as compared to $1.6 million and $1.9 million for the same period ended June 30, 2021.

General and administrative expenses: G&A expenses for the three and six months ended June 30, 2022, were $14.7 million and $24.2 million respectively, or 22.3% and 21.9% respectively of total operating expenses. For the three and six months ended June 30, 2022, G&A expenses increased by $5.6 million and $11.1 million compared to the three and six months ended June 30, 2021, primarily associated with an increase in personnel costs and additional costs incurred in relation to the operation of a listed company. Share-based compensation accounted for $3.3 million and $4.6 million for the quarter and half year ended June 30, 2022, as compared to $1.7 million and $2.0 million for the same periods ended June 30, 2021.

Cash inflows: For the second quarter 2022, Exscientia received $111.0 million in cash inflows from its collaborations as compared to $39.5 million during the second quarter 2021.

Cash, cash equivalents and bank deposits: Cash, cash equivalents and bank deposits as of June 30, 2022, were $732.0 million as compared to $683.7 million as of December 31, 2022. This includes a 12-month fixed term deposit of $121.7 million.

SELECTED CONSOLIDATED STATEMENT OF OPERATIONS, CONSTANT CURRENCY CONVERSION (unaudited)

($ millions, except per share data, at the rate of £1.000 to $1.2162)

Three months ended 
June 30, 

Six months ended 
June 30, 

2022 

2021 

2022 

2021 

Revenue

8.7 

0.4 

17.2 

6.8 

Cost of sales

(10.9) 

(4.4) 

(17.7) 

(9.1) 

Research and development expenses 

(40.2) 

(10.0) 

(68.8) 

(15.1) 

General and administrative expenses 

(14.7) 

(9.1) 

(24.2) 

(13.1) 

Operating expenses

(65.8) 

(23.5) 

(110.7) 

(37.3) 

Foreign exchange gains/(losses)

27.7 

(3.4) 

39.5 

(3.5) 

Loss on forward contracts

(13.7) 

(13.7) 

Other income

1.9 

1.0 

3.6 

1.5 

Operating loss

(41.2) 

(25.5) 

(64.1) 

(32.5) 

Finance income/(expense)

0.4 

0.5 

(0.1) 

Share of loss on joint ventures

(0.3) 

(0.5) 

(0.7) 

(0.9) 

Gain on derivative financial instrument 

0.0 

1.7 

1.7 

Loss before taxation

(41.1) 

(24.3) 

(64.3) 

(31.8) 

Income tax benefit

6.3 

1.7 

10.6 

2.6 

Loss for the period

(34.8) 

(22.6) 

(53.7) 

(29.2) 

Net loss per share

(0.29) 

(0.86) 

(0.44) 

(1.02) 

SELECTED CONSOLIDATED BALANCE SHEET, CONSTANT CURRENCY CONVERSION (unaudited)

($ millions, except per share data, at the rate of £1.000 to $1.2162)

June 30, 2022 

December 31, 2021 

Cash, cash equivalents & short-term bank deposits 

732.0 

683.7 

Total assets

849.0 

779.2 

Total equity

650.8 

689.4 

Total liabilities

198.2 

89.8 

Total equity and liabilities

849.0 

779.2 

SELECTED CONSOLIDATED STATEMENT OF CASH FLOWS. CONSTANT CURRENCY CONVERSION (unaudited)

($ millions, except per share data, at the rate of £1.000 to $1.2162)

June 30, 2022 

June 30, 2021 

Net cash flows from operating activities

63.3 

4.5 

Net cash flows used in investing activities

(133.1) 

(4.2) 

Net cash flows from financing activities

 (3.7) 

222.3 

Net (decrease)/increase in cash and cash equivalents

(73.5) 

222.6 

Net increase in cash, cash equivalents and short-term bank deposits 

48.2 

222.6 

About Exscientia

Exscientia is an AI-driven pharmatech company committed to discovering, designing and developing the best possible drugs in the fastest and most effective manner. Exscientia developed the first-ever functional precision oncology platform to successfully guide treatment selection and improve patient outcomes in a prospective interventional clinical study, as well as to progress AI-designed small molecules into the clinical setting. Our internal pipeline is focused on leveraging our precision medicine platform in oncology, while our partnered pipeline broadens our approach to other therapeutic areas. By pioneering a new approach to medicine creation, we believe the best ideas of science can rapidly become the best medicines for patients.

Exscientia is headquartered in Oxford (England, U.K.), with offices in Vienna (Austria), Dundee (Scotland, U.K.), Boston (Mass., U.S.), Miami (Fla., U.S.), Cambridge (England, U.K.), and Osaka (Japan).

For more information visit us on https://www.exscientia.ai or follow us on Twitter @exscientiaAI.

Forward-looking statements

This press release contains forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995, including with respect to the progress of discovery and development of candidate molecules, and the timing and progress of, and data reported from, clinical trials of Exscientia’s product candidates, and Exscientia’s expectations regarding its projected revenue and cash runway. Any statement describing Exscientia’s goals, plans, expectations, financial or other projections, intentions or beliefs is a forward-looking statement and should be considered an at-risk statement. Such statements are subject to a number of risks, uncertainties and assumptions, including those related to: the impact that the COVID-19 pandemic could have on the Company’s business, including the scope, progress and expansion of Exscientia’s product development efforts; the initiation, scope and progress of Exscientia’s and its partners’ planned and ongoing pre-clinical studies and clinical trials and ramifications for the cost thereof; clinical, scientific, regulatory and technical developments; the process of discovering, developing and commercialising product candidates that are safe and effective for use as human therapeutics; and the endeavour of building a business around such product candidates. In light of these risks and uncertainties, and other risks and uncertainties that are described in the Risk Factors section and other sections of Exscientia’s Annual Report on Form 20-F, filed with the Securities and Exchange Commission (SEC) on March 23, 2022 (File No. 001-40850), and other filings that Exscientia makes with the SEC from time to time (which are available at https://www.sec.gov/), the events and circumstances discussed in such forward-looking statements may not occur, and Exscientia’s actual results could differ materially and adversely from those anticipated or implied thereby. Although Exscientia’s forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by the Company. As a result, you are cautioned not to rely on these forward-looking statements.

To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.

Contact information

Investors:
Sara Sherman
investors@exscientia.ai

Media:
Amanda Galgay
media@exscientia.ai

About Business Wire

Business Wire
Business Wire
24 Martin Lane
EC4R 0DR London

+44 20 7626 1982http://www.businesswire.co.uk

(c) 2018 Business Wire, Inc., All rights reserved.

Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.

Subscribe to releases from Business Wire

Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from Business Wire

Hyatt to Enter Exclusive Collaboration Agreement With Lindner Hotels AG, to Significantly Increase Brand Footprint in Germany and Key European Leisure Destinations6.10.2022 10:36:00 CEST | Press release

Hyatt Hotels Corporation (NYSE: H) announced today that a Hyatt affiliate has entered into an exclusive collaboration agreement with Lindner Hotels AG, a family-run German hospitality business, focused on hotel developments, management and investments. It is expected that more than 30 hotels across seven European countries will join the Hyatt brand portfolio and will be integrated into the World of Hyatt loyalty program in the near future. The majority of the properties are slated to transition to the JdV by Hyatt brand, a collection of independent hotels with unique personalities and a true reflection of their locations. Lindner Hotels AG, a German family-owned hospitality company founded in 1973 by architect Otto Lindner, operates a variety of properties under the Lindner Hotels & Resorts and the me and allhotels brands in key cities across Germany and in Central and Eastern Europe. The agreement will expand Hyatt’s brand footprint to 15 new markets and extend distribution in key des

REPLY: Spike Reply, Live Reply and Glue Reply Named “Partner of the Year” at Kong’s Partner Summit 20226.10.2022 10:08:00 CEST | Press release

Reply announced today that its companies Spike Reply, Live Reply and Glue Reply have been awarded in the EMEA category of the 2022 Partner of the Year Awards from Kong Inc., the cloud native API company. These awards recognize the partners that are driving innovation in the market using APIs, microservices, open source technology and more through Kong products. Winners were announced at Kong’s Partner Summit and Kong Summit 2022, the company’s fifth annual user conference. Filippo Rizzante, CTO of Reply comments: “We are very pleased to receive this award, which confirms our expertise and technical competence of our teams to develop secure and innovative API management infrastructures and connectivity. Our solutions rely on automation and DevSecOps best practices to enable API governance, security, and auditing by making use of API configuration as code. Thus, an API-first strategy can shorten time-to-market and increase security. We support our customers in powering reliable digital c

Neeva Launches in Europe to Rival Google Search With Tracking Free, Ad Free Search6.10.2022 10:00:00 CEST | Press release

Search engine Neeva has today launched in Europe to rival Google, by giving web users honest search results, no tracking, and with absolutely no advertisements or affiliate links. Neeva puts users first and gives consumers control to customise their web search experiences. By eschewing ads and advertisers, Neeva eliminates corporate bias that has plagued the traditional search experience. Instead, Neeva's sole goal is to create a search engine that delivers the best results as quickly as possible. Neeva delivers honest results and empowers users to select their information sources such as news outlets, shopping, software engineering sites, travel and others based on personal preference and relevance, rather than what advertisers suggest, all while respecting users’ privacy by blocking third party tracking and never profiting off of user data. Neeva’s European expansion follows a successful 2021 $40mm Series B funding round. Founded by Sridhar Ramaswamy (ex-SVP of Ads at Google) and Viv

deWiz AB Closes Out Series-B Funding to Fuel Golf Wearable Technology Business6.10.2022 10:00:00 CEST | Press release

deWiz AB has closed out its current Series-B funding round with more than 43 million SEK (nearly 4M USD) in new investment dedicated to its deWiz Golf business. The oversubscribed investment will showcase deWiz’s wearable swing modifying technology through additional marketing, further global expansion, continued product development, and added staffing to support further growth. And with financial backing secured for the golf vertical, deWiz AB can continue development on new verticals, including sports like basketball and tennis, as well as broader applications across gaming and healthcare. The Series-B funding round was backed by the original investors group, and includes new investors like Patrick Rees, founder of Bygghemma, and global deWiz ambassadors Vijay Singh and Annika Sörenstam. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20221006005058/en/ deWiz Golf AB's swing modifier wearable tech, which tracks the exact posi

Etisalat UAE, from e&, bolsters edge cloud solution with uCPE services powered by ADVA and NEC6.10.2022 09:00:00 CEST | Press release

ADVA (FSE: ADV) and NEC Corporation (NEC; TSE: 6701) today announced that Etisalat UAE, the telecoms pillar of e& (formerly known as Etisalat Group), is offering on-demand virtual services to its corporate customers using ADVA’s suite of Ensemble NFV technologies with the solution system integration conducted by NEC in close collaboration with Etisalat UAE, who are onboarding various network functions on top of the platform. The new universal customer premises equipment (uCPE) offering gives enterprises across the Middle East quick and secure access to the industry’s widest range of multi-vendor virtual technologies. With the ability to harness leading virtual network functions (VNFs), including SD-WAN, routing, firewall, DDoS prevention, and IoT applications, Etisalat UAE’s business clients can try out services without risk and seize new revenue opportunities in an instant. “At Etisalat UAE, we continue to enrich businesses by providing best-in-class innovative solutions, harnessing a