Business Wire

CAPRISA and Evotec Launch New Project to Fast-Track New Technology for HIV Prevention

Share

Today, at a side meeting during the AU-EU Ministerial Summit in Kigali, Rwanda, Prof Salim Abdool Karim, Director of CAPRISA, announced a collaboration with a leading life science company Evotec for the designing and development of CAP256, a broadly neutralizing antibody against HIV. The project is a major expansion of the development of an antibody originally developed jointly by CAPRISA and the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases of the US NIH. This new project is a major boost for the CAP256 antibody as a potential tool in the fight against HIV in Africa and showcases the potential of African researchers to fight the continent’s high-burden diseases. The principal aim of the new joint project is to change the course of the HIV epidemic in Africa, which has 70% of the global HIV burden.

CAP256, isolated from a South African woman by CAPRISA and the VRC, has demonstrated a good safety profile in Phase I studies. The next step is to assess if the antibody can prevent HIV infection in humans as effectively as it does in monkeys. If shown to be effective in preventing HIV, the antibody, in conjunction with the VRC’s VRC07 antibody, has the potential to break the HIV infection cycle. However, the difficulties in manufacturing the antibody have been an obstacle in the research and development of CAP256. These obstacles can be overcome and the production of this antibody can be markedly improved.

Mediated by kENUP Foundation, Evotec SE intends to enter into a long-term collaboration with CAPRISA to further optimize and develop CAP256, using innovative approaches they have developed and used successfully with other antibodies. The collaboration will leverage the capabilities at Just – Evotec Biologics in optimizing manufacturing processes through artificial intelligence and machine learning. The result is a more productive manufacturing process for lower cost and wider access for the product. Evotec’s centers of excellence in Redmond (US) and Toulouse (France) will play a key role for enhancing the antibody’s production, facilitating co-formulation of the CAP256-VRC07 combination and manufacturing CAP256 for clinical trials. CAPRISA is conducting clinical trials of these antibodies in conjunction with the Center for Infectious Diseases Research in Zambia, with the support of the European Union – Developing Countries Clinical Trial Partnership.

In the presence of Hon. Dr Daniel Ngamije, Minister of Health of the Republic of Rwanda, Dr Lindiwe Makubalo, WHO Assistant Regional Director for Africa, and Antoine Anfré, French Ambassador to the Republic of Rwanda, the participants of the AU-EU Ministerial Meeting discussed the project’s potential impact on resilience and independence of African health systems.

Prof Salim Abdool Karim, Director of CAPRISA: “We are excited to work with Evotec and the VRC in this project to improve the CAP256 manufacturing processes. It is the culmination of a decade of research to develop CAP256 in order to assess whether this antibody, which originated in Africa, is effective for preventing HIV in Africa.”

Dr Werner Lanthaler, Chief Executive Officer of Evotec SE: “We look forward to collaborate on re-engineering CAP256. We will use and build global capacities to maximize impact for this important product. This is core of our mission to maximize access to modern biologics also in Africa.”

Hon. Dr Daniel Ngamije, Minister of Health, Republic of Rwanda: “Rwanda is focused on creating a biopharmaceutical ecosystem. With the work of CAPRISA and Evotec on monoclonal antibodies, we have the potential to finally ensure Africa’s access to highly effective therapeutics for many diseases endemic to our continent. This effort has Rwanda’s full support.”

About Evotec

Evotec is a life science company with a unique business model that delivers on its mission to discover and develop highly effective therapeutics and make them available to the patients. The Company’s multimodality platform comprises a unique combination of innovative technologies, data and science for the discovery, development, and production of first-in-class and best-in-class pharmaceutical products. Evotec leverages this “Data-driven R&D Autobahn to Cures” for proprietary projects and within a network of partners including all Top 20 Pharma and over 800 biotechnology companies, academic institutions, as well as other healthcare stakeholders. Evotec has strategic activities in a broad range of currently underserved therapeutic areas, including e.g. neurology, oncology, as well as metabolic and infectious diseases. Within these areas of expertise, Evotec aims to create the world-leading co-owned pipeline for innovative therapeutics and has to-date established a portfolio of more than 200 proprietary and co-owned R&D projects from early discovery to clinical development. Evotec operates globally with more than 3,900 highly qualified people. The Company’s 14 sites offer highly synergistic technologies and services and operate as complementary clusters of excellence. For additional information please go to www.evotec.com and follow us on Twitter @Evotec and LinkedIn.

About CAPRISA

CAPRISA is a world-leading AIDS research centre based in Africa. It is renowned for its research that showed that high rates of HIV in Africa are driven by “The Cycle of HIV Transmission” where young women partner with men about 10 years older. CAPRISA provided the first evidence that topical antiretrovirals prevent HIV infection. It has since been leading the development of several new HIV prevention technologies in Africa. The five major partner institutions that constitute CAPRISA are: University of KwaZulu-Natal, University of Cape Town, University of the Western Cape, National Institute for Communicable Diseases and Columbia University in New York. CAPRISA has diverse expertise in basic and molecular epidemiology, virology, immunology, infectious disease medicine, bioinformatics, statistics, ethics and health policy. CAPRISA is headquartered at the Nelson R Mandela Medical School at the University of KwaZulu-Natal in Durban, South Africa.

To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.

Contact information

Press contact

Evotec SE:
Gabriele Hansen, SVP Head of Global Corporate Communications & Marketing,
Phone: +49.(0)40.56081-255
gabriele.hansen@evotec.com

Hinnerk Rohwedder, Senior Specialist Corporate Communications
Phone: +49.(0)40.56081-281
hinnerk.rohwedder@evotec.com

CAPRISA:
Smita Maharaj, Head of Communications, CAPRISA
Phone: +27 82 806 9931
smita.maharaj@caprisa.org

kENUP:
Julia Kärger
Phone: +356 7986 0105
kaerger@kenup.eu

About Business Wire

Business Wire
Business Wire
24 Martin Lane
EC4R 0DR London

+44 20 7626 1982http://www.businesswire.co.uk

(c) 2018 Business Wire, Inc., All rights reserved.

Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.

Subscribe to releases from Business Wire

Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from Business Wire

Soveren Lands Star-Studded $6.5M Seed Round, Including 11 Unicorn Founders, to Fight Privacy Incidents30.11.2021 09:00:00 CET | Press release

Today Soveren announced a $6.5M seed round, led by firstminute capital and joined by Northzone, 11 unicorn founders,and a group of global CEOs. The founders of Airbnb, Datadog, MuleSoft, Snyk, and Color invested alongside Sir Richard Branson’s family, the Chairman CEO of Palo Alto Networks, and others. “Soveren is addressing one of the key technology challenges of the decade: privacy and compliance for Engineering teams. Their product provides CTOs, CISOs, and Privacy Engineers with easy-to-use tools to detect and address privacy gaps. The calibre of their seed round speaks to the pedigree of founders, and to the size of the task ahead,” said Spencer Crawley, Co-Founding General Partner of firstminute capital. Holly Branson, Virgin’s Chief Purpose and Vision Officer said: “At Virgin, our customers mean everything to us and treating them with respect and with world class service is at the core of the entire Virgin ethos. The way we handle their personal information is an important exten

Partech Announces the Closing of Its Second Growth Fund, Partech Growth II, at $750M.30.11.2021 09:00:00 CET | Press release

Partech, the global technology investment firm has announced the closing of Partech Growth II, at €650M (c.$750M) in commitments, significantly above Partech Growth I, raised in 2015 at €400M. The fund, closed above its target size, has seen staunch support from 45+ institutional investors, endowments & foundations, pension funds, life insurers, asset managers and fund-of-funds, and 40+ prominent family offices, entrepreneurs, and business angels, from 10 countries in Europe, North America, and Asia, despite being a mostly remote fundraise due to the pandemic. The fresh capital has already been put to work in five companies in the Czech Republic, France, the Netherlands and Sweden. They include Rohlik - the Prague-based online grocer with full end-to-end operations including procurement, fulfilment, and last mile delivery; Paris-based Skello – the online scheduling and personnel management SaaS tool; Paris-based Rouje – the ultimate French digital native brand of women’s fashion; the A

VicTrack wins Aussie Broadband wholesale deal with ADVA FSP 300030.11.2021 09:00:00 CET | Press release

ADVA (FSE: ADV) today announced that VicTrack is leveraging its state-wide optical transport infrastructure built on ADVA FSP 3000 technology to provide Aussie Broadband with carrier-grade wholesale services. The flexible and fully redundant ROADM network enables VicTrack to easily share capacity. With ADVA’s open optical transport system, it provides VicTrack’s customers with unregenerated optical services between the furthest parts of the state, giving Aussie Broadband access to highly reliable connectivity throughout regional and metro Victoria. Designed for high-capacity and easy scalability, VicTrack’s infrastructure offers unique opportunities for communication service providers (CSPs) to reach new customers. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20211130005076/en/ ADVA’s open optical technology is helping VicTrack to easily roll out wholesale services. (Photo: Business Wire) “Enabling Aussie Broadband to connec

DE-CIX Expands to the Nordics in Cooperation With Bulk Data Centers30.11.2021 08:05:00 CET | Press release

DE-CIX, the world’s leading Internet Exchange (IX) operator and home to the largest carrier and data center neutral interconnection ecosystem globally, today announces its expansion to the Nordic region. DE-CIX has partnered with Bulk Data Centers, which will house DE-CIX IX platforms in Oslo, Norway (OS-IX), Kristiansand, Norway (Campus N01), as well as in Esbjerg, Denmark (Campus DK01). DE-CIX will also be opening IX platforms in Finland. DE-CIX’s expansion into the Nordic region will open the Nordics to international customers, providing 100 percent green-powered Internet Exchanges through Bulk’s data centers. In addition, local Nordic customers will now get faster and more efficient access to global internet exchange services. “The Nordic region comprises some of the world’s most highly developed digital markets,” says Ivo Ivanov, CEO of DE-CIX International, on the company’s expansion to Northern Europe. “However, the interconnection infrastructure available in the region does not

DE-CIX Expands to the Nordics: New Internet Exchanges for Norway, Denmark, and Finland30.11.2021 08:02:00 CET | Press release

DE-CIX, the world’s leading Internet Exchange (IX) operator and home to the largest carrier and data center neutral interconnection ecosystem globally, today announces its expansion to the Nordic region. DE-CIX will be opening IX platforms in Norway, Denmark, and Finland. “The Nordic region comprises some of the world’s most highly developed digital markets,” says Ivo Ivanov, CEO of DE-CIX International, on the company’s expansion to Northern Europe. “However, the interconnection infrastructure available in the region does not match the digital maturity of the economy in the Nordics. The region has seen significant growth in data center investments for the concentration of hosting, storage and cloud deployments, and a high concentration of enterprises and manufacturing presence. It is important for the related interconnection infrastructure to get closer to these investments, to serve the connectivity demands. DE-CIX has seen strong support from the Nordic data center community for our

Kyoto Semiconductor Announces KP-M Monitor Photodiode "KPDE008LS-A-RA-HQ"30.11.2021 08:00:00 CET | Press release

Kyoto Semiconductor Co., Ltd. (President and CEO Tsuneo Takahashi, Head office: Fushimi-ku, Kyoto city), a leading optical device solution manufacturer with world-class technologies and Japanese quality, has announced the new KP-M monitor photodiode, KPDE008LS-A-RA-HQ. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20211129005809/en/ Kyoto Semiconductor KP-M Monitor Photodiode KPDE008LS-A-RA-HQ (Photo: Business Wire) KP-M monitor photodiodes are used to monitor the laser output of optical communication equipment. Higher quality devices are required as the expansion of digital transformation and 5G communications progresses. The "KPDE008LS-A-RA-HQ" has achieved higher quality by adding the probing process at higher temperature. A new wafer prober*1 has been introduced to inspect the electrical characteristics of semiconductor wafers while heated to high temperatures. This allows the inspection to test the temperature (T=75℃) cl

TMD Security Launches Next Generation Key-less Lock Solutions for ATM Safe, Top Box and Access Doors30.11.2021 07:00:00 CET | Press release

TMD Security, global leader in high security ATM and branch access management, announced today the launch of its in-house R&D developed intelligent lock solutions for all types of access points. TMD key-less lock solutions for ATMs and access doors are integrated into TMD High Security Access Management which centrally manages all users and locations with one process and a real-time audit trail. Access for service engineers, branch staff and Cash-in-Transit (CIT) teams is scheduled and pre-approved. At the time of access, user and lock credentials are instantly checked and if correct, an encrypted One Time Code (OTC) is sent directly to the lock via the mobile app. TMD ATM safe lock is unique because the security and intelligence are inside the Lock Controller, located inside the safe behind the door. The OTC is sent directly to the Lock Controller via the mobile app. With no need for a keypad, the Lock Controller is an ‘invisible’ lock for the safe or access door. TMD’s user-friendly