Business Wire

Amylyx Pharmaceuticals Announces New England Journal of Medicine Publication of Pivotal AMX0035 Data Demonstrating Statistically Significant Benefit in People with ALS

Share

Amylyx Pharmaceuticals, Inc., a pharmaceutical company focused on developing new treatments for amyotrophic lateral sclerosis (ALS), Alzheimer’s disease and other neurodegenerative diseases, today announced the publication of results from the pivotal CENTAUR trial evaluating AMX0035 – an investigational neuroprotective therapy designed to reduce the death and dysfunction of motor neurons – in people with ALS in the New England Journal of Medicine (NEJM).

“CENTAUR met its prespecified primary outcome, showing a clinically meaningful and statistically significant treatment benefit on the Revised ALS Functional Rating Scale (ALSFRS-R), the most commonly used scale in clinics worldwide to measure function in ALS,” said Sabrina Paganoni, M.D., Ph.D., principal investigator of the CENTAUR trial, investigator at the Sean M. Healey & AMG Center for ALS at Mass General and Assistant Professor of PM&R at Harvard Medical School and Spaulding Rehabilitation Hospital. “These results represent a major milestone for the ALS community, and I am thrilled about the promise of this therapy for people with ALS.”

The CENTAUR trial of 137 individuals with ALS was conducted across 25 top medical centers in the U.S. through the Northeast ALS (NEALS) consortium. It demonstrated that treatment with AMX0035 was well tolerated and decreased the rate of decline in the ALSFRS-R compared to placebo in people with ALS.

“The data published today in the New England Journal of Medicine show that AMX0035 demonstrated a clinically meaningful benefit and a favorable safety profile for people living with ALS. This development is a breakthrough for the ALS community and we are working collaboratively and expeditiously with agencies worldwide to bring this potential new treatment option forward,” said Josh Cohen, Co-CEO, Chairman and Co-Founder at Amylyx.

“The data published today makes a clear and compelling case that AMX0035 should be made available to people with ALS as soon as possible,” said Calaneet Balas, President and CEO of The ALS Association. “We look forward to working with Amylyx, the FDA, and the entire community to help make that happen. We are grateful to all the Ice Bucket Challenge donors whose contributions helped make this trial possible.”

CENTAUR Results:

Primary Outcomes:

  • After 24 weeks, patients treated with AMX0035 scored on average 2.32 points higher on the ALSFRS-R than the placebo group (p=0.03) using the study’s primary prespecified analysis. A change from baseline analysis was also conducted and indicated that the AMX0035 group scored 2.92 points higher at the end of 24 week follow up (p=0.01).
    • The ALSFRS-R is a 48-point questionnaire measuring daily functions such as the ability to walk, dress independently, self-feed, speak and breathe.
    • Just a 1-2 point change in the ALSFRS-R score can indicate a significant reduction in a patient’s ability to function independently. The ALSFRS-R measures many different daily functions so point differences can manifest differently in different patients. Some examples of a two point change on this scale include the difference between an individual eating successfully with some difficulty vs needing a feeding tube, or walking with assistance versus not walking at all.

Secondary Outcomes:

  • In line with the primary outcome, patients on AMX0035 also showed numerical benefits on secondary outcomes including measures of muscle strength, breathing and hospitalization frequency, although the study was not powered for secondary outcomes.
    • Progression in lung function (percent predicted slow vital capacity) was numerically slower in patients taking AMX0035 (Least Squares Difference=5.11 points, p=0.08).
    • Participants in the AMX0035 group were hospitalized numerically less often (Hazard Ratio = 0.54, p=0.09).
    • Rate of decline in overall muscle strength (percent predicted ATLIS) was numerically slower in patients taking AMX0035 (Least Squares Difference=2.82 points, p=0.12). The effect of AMX0035 on progression was nominally statistically significant for the upper limbs measurements (Least Squares Difference=4.27 points, p=0.04).

Overall Safety:

  • Nearly all participants (46 out of 48 patients in placebo (96%) vs 86 out of 89 patients in the AMX0035 group (97%)) reported one or more treatment-emergent adverse events (TEAEs) during the trial. Most were nonserious, did not lead to modification or interruption of study drug dosing, and were not considered related to the study.
  • Overall, safety was comparable between the groups, with fewer serious adverse events in the active group as compared to the placebo group (9 out of 48 patients (19%) in placebo vs 11 out of 89 patients (12%) in the AMX0035 group).
  • GI adverse events, which were generally characterized as mild by investigators, occurred more frequently in the active group in the first 3 weeks of the trial (28.1% vs 12.5% placebo) and returned to levels comparable to placebo thereafter.

Most CENTAUR participants (77%) were receiving an approved ALS therapy (riluzole, edaravone, or both) during and/or before trial entry. Sensitivity analyses accounting for the duration of treatment under riluzole, edaravone, or both confirmed that the treatment effect of AMX0035 was independent of background approved ALS therapies.

CENTAUR was the recipient of the ALS ACT grant, and is supported by The ALS Association,ALS Finding a Cure, a program of The Leandro P. Rizzuto Foundation, the Northeast ALS Consortium, Healey Center for ALS at Mass General, and was funded in part by the ALS Ice Bucket Challenge.

“I am so proud of the ALS community efforts that made this milestone possible,” said Dr. Merit Cudkowicz, M.D., Chief Medical Officer from ALS Finding a Cure®, Director of the Sean M. Healey & AMG Center for ALS, Chief of Neurology at Mass General, and the Julianne Dorn Professor of Neurology at Harvard Medical School. “The CENTAUR study was designed and run through NEALS, was supported by a partnership between The ALS Association and ALS Finding a Cure, and is a phenomenal example of what can happen when a community works closely together to accelerate ALS progress.”

AMX0035 Long-Term Survival and Extension Data, Future Plans

Participants who completed CENTAUR were given the option after the trial to enroll in an open-label extension study and receive AMX0035 long-term. 92% of eligible CENTAUR participants elected to enroll in the extension study. Interim data from the ongoing open-label extension study are being submitted to a peer-reviewed journal shortly and will be published in the coming months.

Long-term survival analysis for the patients in the AMX0035 and placebo groups has been conducted as well. These data will be submitted to a peer-reviewed journal in the near future.

“We are deeply grateful to all of the CENTAUR participants and our partners who have helped and continue to help develop this important therapy for those living with ALS,” said Justin Klee, Co-CEO and Co-Founder of Amylyx. “We also look forward in the coming months to sharing results from the CENTAUR open-label extension study and the long-term survival analysis, and we will continue to keep the community closely informed on next steps.”

About CENTAUR

CENTAUR was a 24-week, randomized, double-blind, placebo-controlled Phase 2/3 clinical trial that evaluated the safety and tolerability of AMX0035 and assessed the drug’s impact on disease progression as measured by the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) when compared to placebo. The trial also assessed the effects of AMX0035 on other measures that are critical to people with ALS, including muscle strength, lung vital capacity, and biomarkers of neuronal degeneration.

CENTAUR enrolled patients 18-80 years old with definite ALS and within 18 months of symptom onset. The trial did not restrict patients from receiving edaravone or riluzole. More information on the CENTAUR trial can be found at https://amylyx.com/trials/ or www.clinicaltrials.gov, NCT03127514.

About Amyotrophic Lateral Sclerosis (ALS)

ALS is a relentlessly progressive and fatal neurodegenerative disorder caused by motor neuron death in the brain and spinal cord. Motor neuron loss in ALS leads to deteriorating muscle function, the inability to move and speak, respiratory paralysis, and eventually death. The vast majority of patients with ALS (>90%) have sporadic disease, showing no clear family history. Approximately 6000 people are diagnosed with ALS in the United States every year with an approximately similar number of deaths every year.

About AMX0035

AMX0035 is an investigational neuroprotective therapy designed to reduce neuronal death and dysfunction. AMX0035 targets endoplasmic reticulum and mitochondrial dependent neuronal degeneration pathways in ALS and other neurodegenerative diseases.

About Amylyx Pharmaceuticals

Amylyx Pharmaceuticals, Inc. is a pharmaceutical company working on developing a novel therapeutic for amyotrophic lateral sclerosis (ALS), Alzheimer’s disease and other neurodegenerative diseases. For more information, visit www.amylyx.com and follow us on LinkedIn and Twitter.

About The ALS Association

The ALS Association is the largest philanthropic funder of ALS research in the world. The Association funds global research collaborations, provides assistance for people with ALS and their families through its nationwide network of chapters and certified clinical care centers, and advocates for better public policies for people with ALS. The ALS Association builds hope and enhances quality of life while urgently searching for new treatments and a cure. For more information about The ALS Association, visit our website at www.alsa.org.

About ALS Finding a Cure

ALS Finding a Cure® is a research organization dedicated to being a game changer in discovering a cure for this fatal disease. Founded in 2014 by noted philanthropist and Conair Founder and Chairman, Leandro (Lee) Rizzuto, as a tribute to Christie Rizzuto, Lee’s daughter-in-law who was diagnosed with ALS in 2009 at the age of 41, and under the joint leadership of Denis Rizzuto and Peter N. Foss, ALS Finding a Cure® is focused on identifying the gaps in the scientific understanding of ALS that are preventing the development of a cure. The organization, a program of The Leandro P. Rizzuto Foundation, collaborates with a wide range of companies, ALS organizations, other disease non-profits, and ALS patients and families to ensure research efforts are non-duplicative, synergistic, and focused on the ultimate goal: getting to a cure. For more information about ALS Finding a Cure®, visit www.alsfindingacure.org.

About the Northeast ALS Consortium

The Northeast ALS Consortium (NEALS) is an international, independent, non-profit group of over 130 research sites around the world who collaboratively conduct clinical research in Amyotrophic Lateral Sclerosis (ALS) and other motor neuron diseases. The mission of NEALS is to translate scientific advances into new treatments for people with ALS and motor neuron disease as rapidly as possible. The NEALS network is governed by an Executive Committee and the Consortium research activities are advised by an experienced Scientific Advisory Board. Each Leadership team member brings a depth of experience and a unique perspective to the governance of NEALS. Through this leadership, active oversight is provided for ongoing operations along with new approaches to trial design evaluated and implemented.

Contact information

Merissa Muller
Finn Partners
(617) 778-6633
Merissa.Muller@finnpartners.com

About Business Wire

Business Wire
Business Wire
24 Martin Lane
EC4R 0DR London

+44 20 7626 1982http://www.businesswire.co.uk

(c) 2018 Business Wire, Inc., All rights reserved.

Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.

Subscribe to releases from Business Wire

Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from Business Wire

Bavarian Nordic Adopting Veeva CRM and Veeva Vault PromoMats for Digital Launch of New Vaccines28.10.2020 12:03:00 CETPress release

Veeva Systems (NYSE: VEEV) today announced that Bavarian Nordic is adopting multichannel Veeva CRM and Veeva Vault PromoMats for the digital launch of new products in the U.S. and Europe, including Germany, Switzerland, the Nordics, and the Baltics. Specializing in vaccines for infectious diseases, the company needed advanced commercial solutions to support its digital-first strategy. Veeva brings together multichannel engagement and compliant content for the innovative biotechnology company to drive the right interactions with healthcare professionals (HCPs) across the right channels. “Veeva helped us get new digital capabilities and channels up and running fast to meet an aggressive launch timeline and support our global growth plans,” said Robin Kirkby, vice president of commercial operations at Bavarian Nordic. “We now have the commercial foundation in place for digital engagement and to quickly get vaccines to the patients that need them.” Multichannel Veeva CRM enables Bavarian N

Bang & Olufsen Selects CreatorIQ as Global Influencer Marketing Platform of Record28.10.2020 10:00:00 CETPress release

CreatorIQ, the end-to-end enterprise software powering influencer marketing efforts for global enterprises like Unilever, Rakuten, and H&M, today announced it was selected as the platform of record for high-end consumer electronics company Bang & Olufsen (B&O). The Denmark-based company is leveraging CreatorIQ’s sophisticated, data-driven platform to build and optimize its influencer programs, which includes long-term affiliate programs across key global markets. “Influencer marketing is playing an important role in our digital transformation and media diversification, and is integral to reaching new audiences across our key markets in EMEA, LATAM, and North America,” said Alexei Edwards at B&O. “After an extensive search, CreatorIQ was the standout platform for providing the infrastructure for our global efforts - from discovery to recruitment to measurement - while giving us full visibility into the key data points across each stage.” B&O is leveraging CreatorIQ’s advanced data scien

Temenos Names Joaquin De Valenzuela Muley to Lead Digital Banking Growth With Temenos Infinity28.10.2020 09:30:00 CETPress release

Temenos (SIX: TEMN), the banking software company, today announced that it has appointed Joaquin De Valenzuela Muley as Senior Vice President and Business Line Director for Temenos Infinity. Joaquin will lead the global sales and business development of Temenos Infinity, the market-leading digital banking SaaS product. Joaquin will report directly to Jean-Michel Hilsenkopf, Chief Operating Officer at Temenos. Temenos has seen strong demand for Temenos Infinity across challengers and incumbent banks. The company has recently invested over US$1 billion to acquire leading US-based SaaS companies Kony and Avoka to accelerate its digital banking capabilities. Temenos Infinity is the leading SaaS omnichannel digital banking product, covering customer engagement from acquisition and onboarding to origination and account servicing, through to long-term retention. More than 650 clients are using Temenos Infinity including HSBC and Regions. Joaquin joins Temenos from Salesforce, where he led the

Hyperconvergence & Virtualization: VMware Cloud Director Available at IKOULA28.10.2020 09:00:00 CETPress release

Nowadays virtualization and hyperconvergence are among the concerns of many companies, IKOULA – a key player in the European IaaS market - offers its customers the VMware Cloud Director solution: a stable and proven technology allowing them to easily create their private Cloud(s) and operate online their own virtual data center(s). Bringing together in a single secure environment all the storage, computing and network resources necessary for any activities, the VMware Cloud Director solution puts an end to physical infrastructures in silos, and guarantees companies an optimized use of these material resources, with a maximized ROI, controlled costs as well as the interoperability and portability of their applications between their different clouds. What are the benefits for companies using VMware Cloud Director? Simplified provisioning and consumption: users benefit from a single access point, making it very easy to provision all kinds of cloud services, but also third-party services,

Comilog Mine Taps JRC for Private LTE Network28.10.2020 08:30:00 CETPress release

Comilog, the leading manganese company, has decided to build a Private 4G/LTE network in Moanda, Gabon. JRC and Geka Telecom were selected to provide a turnkey solution. JRC will provide the LTE infrastructure for hundreds of subscribers and 4 RF sites, while GEKA Telecom will provide the full services. As part of an effort to modernize the operation process of Moanda mine, Comilog is investing in a modern and secured LTE infrastructure. Field staff will be equipped with ruggedized tablets and smartphones. The target is to digitalize the various processes to increase efficiency and reduce paper. This effort is part of an overall project called Comilog 2020 to increase the capacity of the mine and to enhance local added value. JRC LTE infrastructure was chosen for the quality of its offer. The proposed LTE infrastructure is designed to meet mission critical environment and performance. GEKA Telecom will provide its expertise for the settings of the network and the installation. “We are

Low-Code Meets Cloud Smart: Claris Expands FileMaker Cloud to EMEA Markets28.10.2020 07:00:00 CETPress release

Claris International Inc., an Apple subsidiary and pioneering leader in low-code, today announced the official launch of FileMaker Cloud to EMEA markets. FileMaker Cloud gives EMEA businesses all of the power of the cloud - sharing, rapid deployment, scalability - without compromising on performance or losing connection to the real world of devices, sensors, even offline apps. The result is a future-proof solution that empowers businesses to rapidly create and share intelligent apps with their teams, and integrate them with other popular apps and web services. “For so many businesses, the global pandemic changed every aspect of their business overnight, which led to a massive boom in both low-code adoption and remote work technologies,” said Brad Freitag, CEO of Claris. “In many ways, Claris was built for this moment. Our commitment to low-code without limits - quickly deploying intelligent apps that both solve and evolve - means the solutions our customers build to deal with today’s c