Business Wire

A novel anti-PD-1 agonist antibody with immunosuppressive effect discovered through joint research between Meiji Seika Pharma and the Foundation for Biomedical Research and Innovation at Kobe

Share

Meiji Seika Pharma Co., Ltd. (Headquarters: Tokyo, Japan, President and Representative Director: Daikichiro Kobayashi) and the Foundation for Biomedical Research and Innovation at Kobe (Headquarters: Kobe, Japan, President: Tasuku Honjo, hereinafter ‘FBRI’) announce the discovery of a novel anti-PD-1 agonist monoclonal antibody, which can induce immunosuppressive effect, through their collaborative research on “Treatment of inflammatory diseases, including autoimmune diseases, through the immunosuppressive activity of PD-1” (HBI* Innovation Program) conducted at the FBRI's Dept. of Immunology, Institute of Biomedical Research and Innovation (Professor: Akio Ohta). Part of the findings from the above research was published in "Science Immunology**" issued on January 13, 2023 (Eastern Standard Time). For more information, please visit the FBRI website (URL: https://www.fbri-kobe.org/kbic/english/pressrelease/2023_01-16/).
Meiji Seika Pharma and FBRI are working together to develop the above PD-1 agonist monoclonal antibody as therapeutic candidate for autoimmune diseases.

PD-1 is a molecule expressed on activated lymphocytes and has the function as a suppressor of immune responses. Antibodies that inhibit the function of PD-1 (anti-PD-1 blocking antibodies) can enhance anti-tumor immunity, so that they have been applied to cancer treatment as "immune checkpoint inhibitors."
Through the above joint research supervised by Program Director Tasuku Honjo, Nobel laureate in 2018, Meiji Seika Pharma and FBRI discovered the conditions necessary for inducing immunosuppression by stimulating the function of PD-1 with antibodies. "Anti-PD-1 agonist antibody" is expected to be applied as a novel therapeutic for inflammatory diseases such as autoimmune diseases caused by excessive immune reactions.

Meiji Seika Pharma and FBRI continue to progress the joint research on "anti-PD-1 agonist antibody" and strive to the early contribution of this antibody as a therapeutic agent for autoimmune diseases.

*: HBI: Honjo Kobe Research Center for Biomedical Innovation
**: DOI: 10.1126/sciimmunol.add4947

To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.

Contact information

Meiji Seika Pharma Co., Ltd.:
Public Relations, Corporate Development Dept.
Email: pr-pharma (Please add “@meiji.com” to the end)

Foundation for Biomedical Research and Innovation at Kobe:
Public relations and Strategic planning group
Email: kbic-pr (Please add “@fbri-kobe.org” to the end)

About Business Wire

Business Wire
Business Wire
24 Martin Lane
EC4R 0DR London

+44 20 7626 1982http://www.businesswire.co.uk

(c) 2018 Business Wire, Inc., All rights reserved.

Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.

Subscribe to releases from Business Wire

Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from Business Wire

Cognite Data Fusion ® Achieves Industry First DNV Compliance for Digital Twins30.3.2023 09:04:00 CEST | Press release

Cognite, a global leader in industrial software, in a joint effort with Aker BP, today announced it has successfully achieved DNV-RP-A204 compliance. DNV, the world’s leading classification society and independent expert in assurance and risk management, developed DNV-RP-A204 as a quality-assurance benchmark for the energy industry’s varying approaches to building and operating digital twins. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230329005990/en/ S&P Global Oil & Gas Digital Twin Supplier Landscape, select firms (Graphic: Business Wire) The compliance pertains to Cognite’s core product, Cognite Data Fusion®, an Industrial DataOps platform that combines disparate data sources and information to host, structure, integrate, and contextualize data for digital twin solutions. The assessment scope includes cybersecurity, and software development maturity, including verification and validation process, data quality indicat

Takeda Announces Candidates for Board of Directors at Upcoming Shareholders Meeting30.3.2023 09:00:00 CEST | Press release

Takeda (TSE:4502/NYSE:TAK) announced that its Board of Directors today decided that it will propose a new candidate for independent external director at the 147th Ordinary Meeting of Shareholders on June 28th, 2023. The new candidate, Miki Tsusaka, will join the board effective June 28th, if approved by the shareholders. Furthermore, Masato Iwasaki, Representative Director, Japan General Affairs expressed his intention to retire on the same day. All other current board members who are not our Audit & Supervisory Committee members will be proposed for re-election. “On behalf of Takeda’s Board of Directors, I would like to thank Masato Iwasaki for his invaluable contribution to Takeda. In his nearly 40-year career with Takeda, he has made a significant impact supporting Takeda transformation to become a global biopharmaceutical company, while staying true to our values.” said Christophe Weber, Representative Director, President and Chief Executive Officer of Takeda. Dr. Iwasaki started h

Farmers’ Fintech Agreena Raises €46M to Scale the Regenerative Revolution30.3.2023 08:00:00 CEST | Press release

Climate and fintech company Agreena, whose soil carbon platform is one of the largest globally, today announced its Series B raise of €46M. Led by Germany’s leading multi-stage investor HV Capital, the round has an exciting composition of new investors including impact fund AENU and fintech-focused Anthemis. The equity raise is also supported by a doubling-down from existing shareholders, including evergreen food investor Gullspång Re:food, well-established tech investor Kinnevik and Denmark’s Export and Investment fund. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230329005976/en/ Agriculture-based carbon removals are considered one of the most readily available and easily scaled solutions for climate change mitigation (Photo: Business Wire) The sizable raise comes just one year after the company’s €20M Series A. Since then, Agreena has scaled its activities 10X, expanded its geographic footprint to cover farmland in 16 E

Akkodis Selected by Thales to Deliver Customer Support Engineering Services Worldwide30.3.2023 08:00:00 CEST | Press release

Akkodis, part of the Adecco Group, today announced that it has been selected by Thales to deliver customer support engineering services. Thales is a worldwide technology leader that provides solutions, products and services to the aerospace, defense, transportation and security sectors. In this significant partnership development, Akkodis, a global digital engineering company and Smart Industry leader, has been selected to provide customer support engineering services that span the breadth of Thales’ portfolio, including Integrated Logistics Support (ILS), technical publication and training services. Akkodis’ engineers will work alongside Thales’ teams from ideation through the design and development phases, and beyond to encompass the in-service support phase. This will help to ensure that products and solutions are optimized to accommodate the in-service qualities of safety, reliability and maintenance, as specified by Thales’ end customers. The engineers will also author technical d

AMWC 2023: Data From Sculptra® Cheek Wrinkle and Alluzience® Star Studies Reinforce Strength of Galderma’s Broad Aesthetic Portfolio30.3.2023 07:00:00 CEST | Press release

Galderma will be presenting the latest data from the Sculptra® (injectable poly-L-lactic acid, PLLA-SCA) Cheek Wrinkle and Alluzience® (abobotulinumtoxinA solution) STAR studies at the 21st Aesthetic & Anti-Aging Medical World (AMWC) Congress, taking place in Monaco, from March 30 to April 1, 2023. Results demonstrate high aesthetic improvement as well as patient and investigator satisfaction for both products, reinforcing the strength of the company’s highly differentiated aesthetic portfolio, and underscoring its commitment to delivering science, innovation, and a premium experience throughout the treatment journey.1,2 Data from the innovative Sculptra Cheek Wrinkle study, a large clinical registration trial in the United States, show the long-lasting effectiveness of the treatment for cheek wrinkle correction over a two-year period.1 Sculptra is the first and original collagen stimulator with the unique PLLA-SCA3,4,5,6,7,8 that addresses the root causes of the skin aging process by