Sirius Therapeutics Announces Submission to Begin First Clinical Trial of Factor XI siRNA, a Long-Acting Next-Generation Anticoagulant for Thromboembolic Disorders
Sirius Therapeutics today announced it has submitted an application in Australia to begin a first-in-human clinical trial of SRSD107, its next generation siRNA therapeutic for the prevention and treatment of thromboembolic disorders. SRSD107, which specifically targeting coagulation factor XI (FXI), is the first Sirius-developed compound to reach clinical stage of development globally.
“We have made rapid progress in developing SRSD107 and other candidates in our pipeline since Sirius was established two years ago. This submission marks our transition from discovery to clinical stage development,” said Dr. Qunsheng Ji, Sirius Therapeutics Chief Executive Officer. “The exceptional durability of pharmacology and safety profile suggests SRSD107 has the potential to be a Best- and First-in-class FXI siRNA therapeutic. We aspire to develop SRSD107 as a transformative medicine with a dosing schedule of once semiannually or potentially annually for patients who need chronic anticoagulant.”
About Thromboembolic Disorders
Thrombosis is the common underlying mechanism of most cases of myocardial infarction, ischemic stroke, and venous thromboembolism (VTE). According to a study in The Lancet of reginal and global mortality, thromboembolic disorders are estimated to cause 1 in 4 deaths worldwide1.
About SRSD107
SRSD107 is a novel double-stranded small interfering ribonucleic acid (siRNA). Developed by Sirius Therapeutics, SRSD107 specifically targets coagulation factor XI (FXI) mRNA and inhibits FXI protein expression, thereby blocking the intrinsic coagulation pathway and promoting anticoagulant/anti-thrombotic effects. Preclinical in vivo studies demonstrated near 100% reduction of FXI levels for up to 6 months, without bleeding events after a single subcutaneous dose.
About Sirius Therapeutics
Sirius is an innovative biotech company developing next generation siRNA therapy for global markets. We are dedicated to discovering and developing new treatment options for cardiovascular disease patients.
Founded in 2021 by a world-class leadership team and investors, Sirius has established an innovative discovery center in the United States and translational medicine center in China. Sirius has raised nearly US$100 million funding to date from OrbiMed, Creacion Ventures, Hankang Capital, Delos Capital, and the leadership team.
[1] Lozano R, Naghavi M, Foreman K, et al. Lancet. 2012;380, 2095-1128.
To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.
View source version on businesswire.com: https://www.businesswire.com/news/home/20231109502078/en/
Contact information
About Business Wire
Business Wire(c) 2018 Business Wire, Inc., All rights reserved.
Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Reibus International Announces CEO Transition29.11.2023 20:00:00 CET | Press release
Reibus International, the world’s largest online marketplace for metals, announces the appointment of Temy Mancusi-Ungaro as its new Interim Chief Executive Officer. The decision to bring Temy on board reflects a new era of investment in the company and Reibus’ continued commitment to driving innovation and growth in the metals industry. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20231129023580/en/ Temy Mancusi-Ungaro (Photo: Business Wire) With over 17 years of experience in the B2B Software industry, Temy is a seasoned operator who brings a proven track record of scaling innovative B2B companies, including Reachdesk, Electric, Yext, and CityGrid. He most recently held the position of CEO at Reachdesk, where his acumen for navigating the complexities of scaling a business led the company to be named among the top 100 fastest-growing products, according to G2, for three years in a row. "We are thrilled to welcome Temy to t
Tongxin Micro Making a Splash at TRUSTECH, and Unveiling the World’s First eSIM Solution Tailored for Smart POS Systems29.11.2023 18:00:00 CET | Press release
November 28th marks the grand opening of TRUSTECH 2023 in Paris, France. Tongxin Micro, an industry-leading semiconductor solution provider, makes an impressive debut, showcasing its technological advancements in identity recognition, telecommunications, and financial payments. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20231129462718/en/ (Photo: Business Wire) In the realm of identity recognition, Tongxin Micro brings its document chip solutions in compliance with international ICAO standards that boast the highest security levels globally, catering to such applications as seafarer’s passport and official passport. In telecommunications, a full array of products and terminal applications are displayed, including standard SIM, SWP-SIM, digital car keys based on SWP-SIM, and eSIM wearable devices. In the payment sector, Tongxin Micro’s innovative payment technologies draw significant attention, ranging from chip application
Gillette Gaming launches new creative concept, Hit Reset with Gillette, to encourage and inspire gamers and fans worldwide29.11.2023 17:15:00 CET | Press release
For over ten years, GilletteTM, the world’s largest male grooming company, has been helping gamers look and play their best, whether it be for gaming or everyday life. This year, Gillette is refreshing its approach and creating a new era of gaming with its newest campaign, “Hit Reset with Gillette” – encouraging the gaming community to hit reset after a night of gaming, come back a better player and look sharp for the day with a fresh shave. Hitting “reset” is a universal term in gaming and works perfectly with grooming – inviting gamers and fans to start their day looking and feeling their best, to be their best and most confident, whether it be in gaming or whatever the day has ahead. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20231129843095/en/ (Graphic: Business Wire) To further inspire the gaming community, Gillette will leverage its Gillette Gaming Alliance to create “Hit Reset with Gillette” content and host branded
Kahuna Workforce Solutions Secures $21 Million in Series B Funding from Resolve Growth Partners to Advance Skills Management Technology for Frontline Workers29.11.2023 17:08:00 CET | Press release
Kahuna Workforce Solutions, the leading provider of operational skills and competency management software, today announced a $21 million Series B funding round led by Resolve Growth Partners. This investment marks a significant milestone in Kahuna’s growth journey and solidifies the criticality of skills management for industries with technical frontline workforces. As organizations navigate an ever-evolving and complex landscape, understanding, validating, and aligning workforce skills to strategic business objectives is central to operating at the highest level. Kahuna is at the forefront of skills management technology, equipping organizations with actionable skill insights for effective assessment, training and development, and staffing and deployment initiatives, ultimately enabling resilient operations, improved productivity, and a more competitive workforce. Kahuna’s customer base of leading Fortune 500 energy, manufacturing, and field service organizations, and world-renowned h
OPP SCIENCE Reaffirms Its Commitment to Public Security by Supporting the AGIR Meetings Sponsored by French National Gendarmerie29.11.2023 16:45:00 CET | Press release
OPPSCIENCE, a leader in Intelligence Analysis Management (IAM), reaffirms its support for public security by sponsoring the AGIR event. Following the introduction of its latest version of SPECTRA, a software dedicated to law enforcement, during Milipol Paris, OPPSCIENCE contributes to accelerating the initiatives of the National Gendarmerie on the seek of innovations. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20231129543708/en/ The encounters at AGIR supported by OPPSCIENCE (Photo: Business Wire) MEETINGS AT AGIR: UNDERSTANDING THE NEEDS OF THE GENDARMERIE FOR LAW ENFORCEMENT Strengthening the dialogue between law enforcement and the technology industry is the goal of the AGIR exhibition (Accompagnement par la Gendarmerie de l’Innovation, de l’Industrie et de la Recherche). Initiated by the innovation unit of the National Gendarmerie, this exhibition enables innovators in the Gendarmerie community, specialized units, proj