Biocytogen/Eucure Biopharma to Present Complete Clinical Data from YH003 (anti-CD40 mAb) Phase I Trial at ESMO 2023
Eucure Biopharma, a wholly owned subsidiary of Biocytogen Pharmaceuticals (Beijing) Co., Ltd. ("Biocytogen", HKEX: 02315), will attend and present a poster at the ESMO Congress 2023, taking place in Madrid, Spain from October 20-24, 2023. The poster will summarize data from a completed phase I study of YH003, an independently developed anti-CD40 monoclonal antibody (mAb).
Poster title: Phase I open-label, dose escalation and expansion study of YH003, an anti-CD40 agonist monoclonal antibody in combination with toripalimab in patients (pts) with advanced solid tumours.
Presenting author: Dr. Ben Markman
Clinical Trial #: NCT04481009
Final publication number (FPN): 1041P
Category: Investigational immunotherapy
Presentation date: Monday 23 October
Clinical data indicates that YH003 has favorable pharmacokinetics, and is well tolerated when used in combination with the anti-PD-1 mAb Toripalimab. The combination therapy has also shown encouraging anti-tumor activity in patients with advanced solid tumors.
YH003 is a humanized IgG2 agonistic anti-CD40 monoclonal antibody. Whether used as a single agent or in combination with anti-PD-1 monoclonal antibody drugs, YH003 demonstrated strong anti-tumor effects in multiple tumor models in Biocytogen’s humanized CD40 mice, without exhibiting hepatotoxicity or other toxicities. Pharmacodynamic studies in mice indicates that YH003 significantly increased the infiltration of anti-tumor T cells into tumors. Currently, YH003 is undergoing phase II multi-regional clinical trials (MRCTs) for the treatment of patients with unresectable/metastatic pancreatic ductal adenocarcinoma (PDAC) and melanoma.
As a wholly owned subsidiary of Biocytogen, Eucure Biopharma undertakes the mission of clinical development for Biocytogen’s R&D pipelines. Relying on a strong clinical development team and extensive clinical development experience, Eucure Biopharma focuses on antibody drug therapy for oncology and other indications. The company has established a product pipeline for more than 10 targets, with 1 asset in Phase II MRCTs, 3 assets in phase I clinical trials and 1 asset having received IND approvals. For more information, please visit www.eucure.com.
Biocytogen (HKEX: 02315) is a global biotechnology company that drives the research and development of novel antibody-based drugs with innovative technologies. Using its proprietary RenMab™/RenLite®/RenNano® mice platforms for fully human monoclonal, bispecific/multispecific antibody and nanobody development, Biocytogen has integrated its in vivo drug efficacy screening platforms and strong clinical development expertise to streamline the entire drug development process. Biocytogen is undertaking a large-scale project to develop first-in-class and/or best-in-class antibody drugs for more than 1000 targets, known as Project Integrum (RenMice® HiTS Platform). As of June 30, 2023, 50 therapeutic antibody co-development/out-licensing/transfer agreements and 42 target-nominated RenMice® licensing projects have been established worldwide, including several partnerships with multinational pharmaceutical companies (MNCs). Biocytogen's pipeline is comprised of 10 core assets, with partnerships established for multiple clinical assets. Headquartered in Beijing, Biocytogen has branches in China (Haimen Jiangsu, Shanghai), USA (Boston, San Francisco), and Germany (Heidelberg). For more information, please visit http://en.biocytogen.com.cn.
To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.
About Business Wire
(c) 2018 Business Wire, Inc., All rights reserved.
Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
BuildRI Announces Top 2023 Responsible Investment Programs of European Alternative Investors30.11.2023 22:46:00 CET | Press release
BuildRI, a leading provider of responsible investment insights, is pleased to unveil the leading responsible investment programs within the European alternative investment sector for the year 2023. Throughout the course of the year, BuildRI's team of seasoned analysts has assessed multiple alternative investment firms, employing a comprehensive set of 32 responsible investment and Environmental, Social, and Governance (ESG) criteria. These criteria encompass the integration and maturity level of responsible investment policies, programs, and practices adopted by these firms. It is worth noting that the evaluation criteria are closely aligned with industry-leading ESG and responsible investment standards and frameworks. The data utilized for evaluation is primarily sourced from publicly-disclosed or self-reported information. Comprehensive rankings, benchmarking data, and additional information about each leading firm is available on the BuildRI platform for its members. The leading res
Mary Kay Expands to Hungary, Elevating Beauty and Empowerment in Central Europe30.11.2023 19:03:00 CET | Press release
Mary Kay Inc., the iconic beauty brand and global advocate for women’s empowerment, is thrilled to announce its expansion into Hungary, a strategic move that marks the company's latest foray into the European market. This expansion coincides with Mary Kay's milestone 60th anniversary, underscoring its enduring legacy of offering unparalleled entrepreneurship opportunities and high-quality skincare and color cosmetics. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20231130602889/en/ With Hungary’s rich cultural tapestry, vibrant heritage, and dynamic economy, Mary Kay Inc. is set to introduce a range of initiatives aimed at bolstering the economic empowerment of Hungarian women. (Credit: Mary Kay Inc.) Mary Kay Hungary's operations will be overseen from the Mary Kay Czech Republic's offices in Prague. To celebrate this momentous expansion, events in both Prague and Budapest have been arranged. This expansion builds upon the br
Q4 Inc. Announces Fourth Quarter 2023 Q4 Platform Release30.11.2023 18:00:00 CET | Press release
Q4 Inc. (TSX: QFOR) (“Q4” or “the Company”), the leading capital markets access platform, announced today its fourth quarter 2023 release of innovative enhancements to the Q4 Platform that will continue to deliver value to their clients through seamless workflows, insights, and analytics. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20231130813795/en/ Q4 Issuer Dashboard Q4 Platform Release: Fourth Quarter 2023 Issuer Dashboard: Improved Web Management App Issuers can now use the Web Management app to make accelerated website updates and have greater visibility into the status of their web requests. The homepage also gives them direct access to highlighted critical alerts, including activist engagements, and real time updates on events. Engagement Analytics App: Smarter Insights Through the Engagement Analytics app, Investor Relations Officers (“IROs”) will now have access to historical data on investor engagement to more ea
ISFC to Focus on Central Role of Forestry Sector at COP2830.11.2023 17:56:00 CET | Press release
The International Sustainable Forestry Coalition (ISFC) will be representing some of the world’s largest companies engaged in sustainable forestry at COP28, and will be promoting the role of forestry and land-use in the global climate transition. Nations must find a way to reduce emissions by 43% by 2030 if we are to avoid the worst effects of climate change. With greater investment, forestry and land management could contribute up to 25% of the emissions reductions needed to reach net zero. It is widely expected at COP that there will be more focus on the role that sustainably produced timber can play in the built environment, and ISFC will be taking a leading role in these discussions and promoting the expanded contribution of the forestry sector to the decarbonization of the global economy. Dr. David Brand, Convening Chair of ISFC and Executive Chair of New Forest, commented, “The global climate effort requires expanded investment in sustainable land-use and sustainable materials in
Aviz Networks Expands Funding to $10M With New Investments From Accton, Cisco Investments and Wistron30.11.2023 16:32:00 CET | Press release
Aviz Networks, a leader in open networking software for cloud-scale infrastructures serving telecom and enterprises, today announced it has added Cisco Investments to its latest funding expansion, joining existing investors, Moment Ventures, Accton and Wistron. This funding round, now reaching $10M, will accelerate customer momentum for Aviz’s multi-vendor, GenAI-based networking stack along with adoption of SONiC based open networking. Aviz helps organizations achieve the performance and cost benefits of hyperscale networks by removing complexity and supplying AI-driven management features as part of a breakthrough Networking 3.0 software stack. Aviz’s stack supports the fast-growing SONiC open-source network OS (NOS) as well as multi-NOS environments and leverages the power of large-language-models (LLMs) to deliver unparalleled choice and capabilities. The company has seen rapid growth over the past 12 months, scaling its number of customers, revenue, and operational headcount to me