RS Oncology Announces New Preclinical Data Show RSO-021 May Block and/or Reverse the Progression of Aggressive Mesotheliomas, Improving Druggability
RS Oncology, a clinical stage biotechnology company developing innovative therapies to eradicate mesothelioma and other diseases, was part of a collaboration that recently shared new preclinical data at the IASLC 2023 World Conference on Lung Cancer in Singapore. The data, presented by Dr. Dean Fennell, represented a partnership between RS Oncology and other lead research institutions, including the University of Leicester and the Cunniff Laboratory at the University of Vermont Cancer Center.
This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20230912702236/en/
“Sarcomatoid tumors are highly resistant to anti-cancer therapies, and many patients run out of available treatment options. Our findings here might have unveiled a druggable ‘Achilles Heel’ against this terrible disease,” said Dr. Fennell, presenting author on the study. Dr. Fennell and Dr. Cunniff shown at lunch during AACR conference 2023. (Photo courtesy of George Naumov)
Mesotheliomas can transform from a less aggressive epithelioid malignancy to a more aggressive sarcomatoid form. Using biphasic mesotheliomas as a model containing both epithelioid and sarcomatoid features, investigators at the University of Leicester, led by Dr. Fennell, conducted a geospatial analysis of patient tissues to explore the molecular signatures associated with the histological regions.
Using sophisticated spatial analysis tools coupled with machine learning approaches, the group found that the more aggressive sarcomatoid regions had distinct molecular signatures driving pro-tumor pathways, drug resistance, and increased metastatic potential. These findings were validated across an independent cohort of 150 mesothelioma patient tissues. Notably, tumor regions containing sarcomatoid tissue showed features of increased resistance to oxidative stress – a critical tumor cell adaptation for survival.
In collaboration with Dr. Brian Cunniff’s laboratory, the team then evaluated molecular signatures of human biphasic mesothelioma tumor cells following treatment with the irreversible PRX3 inhibitor RSO-021, which is currently being evaluated in a Phase 1/2 clinical trial in patients with malignant pleural effusion caused by advanced/metastatic solid tumors (NCT05278975). RSO-021 treatment reversed the gene signatures associated with epithelial-to-sarcomatoid transition, including downregulation of hypoxia, glycolysis, and epithelial-to-mesenchymal transition (EMT)-associated genes. These results suggest that this transition, thought to be unidirectional in nature, may be PRX3-dependent, druggable, and now reversible.
“Sarcomatoid tumors are highly resistant to anti-cancer therapies, and many patients run out of available treatment options. Our findings might have unveiled a druggable ‘Achilles Heel’ against this terrible disease,” said Dr. Fennell, presenting author on the study. “The ability to treat such tumors with RSO-021 and revert them to epithelioid malignancies could delay or even prevent emergence of the most aggressive features associated with mesothelioma. Further, RSO-021 could potentially sensitize them to other treatments.”
Abstract Number: MA17.11
Session:MA17 - Current Standards and Future Directions in Mesothelioma
Title: Spatial Transformation in Mesothelioma Involves a Hypoxia-TGF Beta-EMT Axis that is Reversible via PRX3 Inhibition
Date: Tuesday, September 12, 10:45 AM UTC +8
About RS Oncology
RS Oncology (RSO) is a clinical stage biotechnology company based in Cambridge, Massachusetts with a mission to eradicate mesothelioma and other diseases worldwide through novel science and an innovative business model.
To view this piece of content from cts.businesswire.com, please give your consent at the top of this page.
Jarrett Duncan, CEO
About Business Wire
(c) 2018 Business Wire, Inc., All rights reserved.
Business Wire, a Berkshire Hathaway company, is the global leader in multiplatform press release distribution.
Subscribe to releases from Business Wire
Subscribe to all the latest releases from Business Wire by registering your e-mail address below. You can unsubscribe at any time.
Latest releases from Business Wire
Takeda’s Dengue Vaccine Recommended by World Health Organization Advisory Group for Introduction in High Dengue Burden and Transmission Areas in Children Ages Six to 16 Years3.10.2023 22:50:00 CEST | Press release
Takeda (TSE:4502/NYSE:TAK)today announced that the World Health Organization’s (WHO) Strategic Advisory Group of Experts (SAGE) on Immunization shared recommendations for use of QDENGA®▼ (Dengue Tetravalent Vaccine [Live, Attenuated]) (TAK-003). In the coming months, the WHO will consider the SAGE recommendation and update its position paper on dengue vaccines to include final guidance on the use of QDENGA in public vaccination programs. SAGE made the following recommendations: The vaccine to be considered for introduction in settings with high dengue disease burden and high transmission intensity to maximize the public health impact and minimize any potential risk in seronegative persons. The vaccine to be introduced to children aged 6 to 16 years of age. Within this age range, the vaccine should be introduced about 1-2 years prior to the age-specific peak incidence of dengue-related hospitalizations. The vaccine should be administered in a 2-dose schedule with a 3-month interval betw
Verimatrix To Showcase Cybersecurity Solutions at GovWare 20233.10.2023 17:45:00 CEST | Press release
Regulatory News: Verimatrix, (Euronext Paris: VMX), the leader in powering the modern connected world with people-centered security, today announced it will highlight its Extended Threat Defense (XTD) technologies at GovWare 2023 taking place October 17-19 at Singapore’s Sands Expo and Convention Centre. Located in GovWare booth C19, Verimatrix will offer hands-on demonstrations as well as customer success stories for its portfolio of award-winning XTD cybersecurity solutions that enable mobile app developers to harness the latest protections against hackers seeking to use mobile apps and websites as tools to attack enterprises. GovWare 2023 promises yet another invigorating event where knowledge, ideas, insights and technologies will be shared among cybersecurity leaders and innovators. Under the theme “Fostering Trust Through Collaboration in the New Digital Reality,” GovWare 2023, a part of the renowned Singapore International Cyber Week (SICW), is set to deliver transformative insi
Evolve Additive Solutions Announces Strategic Partnership with alphacam to Provide STEP Parts Production in Europe3.10.2023 16:00:00 CEST | Press release
Evolve Additive Solutions, provider of industrial 3D printing solutions and inventor of the transformative Selective Thermoplastic Electrophotographic Process (STEP), announces a strategic partnership with alphacam GmbH to offer STEP-manufactured parts as a service to customers throughout Europe. STEP is a groundbreaking additive manufacturing technology that addresses the manufacturing constraints in accuracy, scalability and engineering-grade materials by other technologies in market today. alphacam will combine its deep industry expertise, vast experience in printing plastic parts, and strong customer relationships with its adoption of Evolve’s Scaled Volume Production (SVP) platform to produce and deliver fully dense, high-fidelity thermoplastic parts with near injection molding surface finish and properties. This marks the 2nd partnership of this kind introduced by Evolve as part of its mission to establish STEP production centers of excellence around the world – ultimately to inc
Axius Water acquires Triplepoint Environmental, a leader in transforming wastewater lagoons3.10.2023 15:39:00 CEST | Press release
Axius Water announced today that it has acquired Colorado-based Triplepoint Environmental, a leading supplier of wastewater lagoon systems for rural communities. Axius Water is a portfolio of businesses focused on improving the effectiveness of water and wastewater treatment for industrial and municipal customers. The acquisition of Triplepoint complements Axius Water’s established expertise in nutrient management and further expands the company’s capabilities in lagoon technology. This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20231003371312/en/ Founded in 2007, Triplepoint provides high-performing, high-value lagoon solutions for industrial and municipal customers across the U.S. and Canada. Triplepoint’s innovative lagoon technologies, including its flagship Ares Aerator solution, utilize existing infrastructure to ease the financial burden of upgrades while reinventing lagoons to meet new, more stringent effluent limits. A
Economist Impact Research Finds 85% of Organizations’ Ability to Adapt Falls Short3.10.2023 15:00:00 CEST | Press release
Planview, a global leader in Portfolio and Value Stream Management, today announced the findings of a global study, “Bridging the gap: turning strategy into reality,” conducted by Economist Impact, the research arm of The Economist,and commissioned by Planview. The study uncovers common disconnects in strategy implementation leading to failures in critical digital initiatives. The findings show a stark reality: if businesses do not accelerate efforts to close the gap between strategy and action, the consequences are significant: wasted work, sunk costs, failed digital transformations, and the threat of becoming obsolete. “With economic uncertainties, market disruptions, the rapid advancement of technologies like AI, and the growing digitalization imperative impacting every industry, the pace of change and complexity of decision-making is growing exponentially. Organizations across the globe are experiencing the realities of ‘adapt, evolve, or die.’ Yet only 15% of executives are confid