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Sequana Medical announces Extraordinary General Meeting of Shareholders on 10 February 2023

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PRESS RELEASE
REGULATED INFORMATION
11January 2023, 07:00 am CEST


Ghent, Belgium11 January 2023Sequana Medical NV (Euronext Brussels: SEQUA) (the "Company" or "SequanaMedical"), a pioneer in the treatment of fluid overload in liver disease, heart failure and cancer, today invites the holders of securities issued by the Company to attend the Extraordinary General Meeting of Shareholders on Friday, 10 February 2023.

The items on the agendas of the meeting include (amongst other things) the proposed approval of the appointment of Douglas Kohrs and Alexandra Taylor Clyde as independent non-executive directors, the approval of certain amendments to the Company's remuneration policy, and the issuance of "Kreos Subscription Rights" (in the form of subscription rights).

The Extraordinary General Meeting of Shareholders will take place at the Company's registered offices in Ghent and will start at 09:00 am CEST. The full convening notice with the agenda and proposed resolutions can be accessed on the Sequana Medical website: www.sequanamedical.com/investors/shareholder-information.

In light of the COVID-19 pandemic, it is possible that certain measures imposed by the Belgian government to deal with this pandemic may (still) be in effect on the date of the Extraordinary General Meeting of Shareholders. Therefore, the Board of Directors recommends that the holders of securities issued by the Company that wish to participate to the meeting make use, as much as practically possible, of the right to vote through voting by mail or by means of a written proxy to the Chair of the Board of Directors.

The Company will grant access to the meeting to security holders, proxy holders and other persons only to the extent permitted in light of the measures taken or to be taken by the authorities as applicable on the date of the meeting, and always taking into account the recommendations of the authorities, and safety and health considerations.

The Company recommends the holders of its securities to use e-mail for all communications with the Company regarding the Extraordinary General Meeting of Shareholders. The Company's e-mail address for such communications is: IR@sequanamedical.com.

For more information, please contact:

Sequana Medical
Lies Vanneste
Director Investor Relations
E: IR@sequanamedical.com
T: +32 (0)498 05 35 79

Optimum Strategic Communications
Mary Clark, Nick Bastin, Vici Rabbetts
E: Sequana@optimumcomms.com
T: +44 (0)7931 500 066

About Sequana Medical

Sequana Medical NV is a pioneer in treating fluid overload, a serious and frequent clinical complication in patients with liver disease, heart failure and cancer. These patients can have up to 15 liters of extra fluid in their bodies, causing major medical issues including increased mortality, repeated hospitalizations, severe pain, difficult breathing and restricted mobility that severely impacts daily life. Although diuretics are standard of care, the problem is that in many patients they are no longer effective and / or tolerable. There are limited effective treatment options for these patients resulting in poor clinical outcomes, high costs and major impact on their quality of life. Sequana Medical is seeking to provide innovative treatment options for this large and growing “diuretic-resistant” patient population.

alfapump® and DSR® are Sequana Medical's proprietary platforms that work with the body to treat diuretic-resistant fluid overload, delivering major clinical and quality of life benefits for patients and reducing costs for healthcare systems. The Company has reported positive primary endpoint data from the North American pivotal POSEIDON study of the alfapump in recurrent or refractory ascites due to liver cirrhosis, enabling the filing of a Pre-Market Approval (PMA) application with the FDA, planned for H2 2023. Having delivered clinical proof-of-concept for DSR as a disease-modifying drug program for the treatment of heart failure, the Company is planning to commence MOJAVE, a US multi-centered randomized controlled Phase 1/2a clinical study of DSR 2.0, in H1 2023.

Sequana Medical is listed on Euronext Brussels (Ticker: SEQUA.BR) and headquartered in Ghent, Belgium. For further information, please visit www.sequanamedical.com.

Important Regulatory Disclaimers

The alfapump® system is currently not approved in the United States or Canada. In the United States andCanada, the alfapump system is currently under clinical investigation (POSEIDON Study) and is being studied inadult patients with refractory or recurrent ascites due to cirrhosis. For more information regarding thePOSEIDON clinical study see www.poseidonstudy.com. DSR® therapy is still in development and it should benoted that any statements regarding safety and efficacy arise from ongoing pre-clinical and clinicalinvestigations which have yet to be completed. DSR therapy is currently not approved for clinical research in theUnited States or Canada. There is no link between DSR therapy and ongoing investigations with the alfapumpsystem in Europe, the United States or Canada.

Note: alfapump® is a registered trademark. DSR® is a registered trademark in the Benelux, China, the EU, UnitedKingdom, and Hong Kong.

Forward-looking statements

This press release may contain predictions, estimates or other information that might be consideredforward-looking statements. Such forward-looking statements are not guarantees of future performance.Theseforward-looking statements represent the current judgment of Sequana Medical on what the futureholds,and are subject to risks and uncertainties that could cause actual results to differ materially. Sequana Medicalexpressly disclaims any obligation or undertaking to release any updates or revisions to any forward-lookingstatements in this press release, except if specifically required to do so by law or regulation. You should notplace undue reliance on forward-looking statements, which reflect the opinions of Sequana Medical only as ofthe date of this press release.

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