GlobeNewswire

ProMIS Neurosciences Outlines Best-in-class Approach to Amyloid-beta-targeting Drug Candidates for Alzheimer’s Disease

Share

Dr. Johanne Kaplan highlights need for precision selectivity for the toxic form of amyloid beta in narrated overview

TORONTO and CAMBRIDGE, Mass., Nov. 07, 2019 (GLOBE NEWSWIRE) -- ProMIS Neurosciences, Inc. (TSX: PMN) (OTCQB: ARFXF), a biotechnology company focused on the discovery and development of antibody therapeutics targeting toxic oligomers implicated in the development of neurodegenerative diseases, posted a narrated overview of its next-generation amyloid-beta (Aβ)-targeting drug candidate, PMN310 for Alzheimer’s disease (AD), juxtaposed with Biogen’s first-generation candidate, aducanumab. The narrative details PMN310’s superior binding to the toxic form of Aβ, amyloid beta oligomers (AßOs), potentially without the dose-limiting side effect, ARIA-E (brain swelling), associated with aducanumab. Upon regulatory approval of aducanumab, PMN310 is positioned to be a next-generation, amyloid-beta-targeting candidate for AD.

Biogen has announced plans to submit aducanumab to the U.S. Food and Drug administration (FDA) for approval. As part of its announcement, the company noted the potential implication of its decision for similar approaches targeting amyloid beta. As a next-generation approach to targeting Aβ, PMN310 offers precision selectivity for AßOs, which hundreds of studies indicate are a root cause of neuronal death in AD. In pre-clinical studies, PMN310, unlike aducanumab, shows virtually no binding to amyloid plaque, suggesting a best-in-class profile with an opportunity for higher dosing without ARIA-E.

Stated Dr. Johanne Kaplan, Chief Development Officer for ProMIS Neurosciences: “As the renowned neuroscience leader Dr. Dennis J. Selkoe wrote in a recent STAT First Opinion byline, the first therapy for Alzheimer’s will ‘open the floodgates to make better versions.’ PMN310 could be the first of these better versions. Pre-clinical data show PMN310 can neutralize toxic oligomers without binding to plaque. Plaque binding is associated with the dose-limiting brain swelling observed in 35% of the patients given aducanumab in its phase 3 program. In many chronic conditions, first generation therapies are often clinically eclipsed by better versions. PMN310 is on track to provide this better version, achieving greater therapeutic potency for patients without the dose-limiting side effect of brain swelling.” (“Biogen’s good news on aducanumab could ‘open the floodgates’ for Alzheimer’s drugs,” by Dennis J. Selkoe, October 23, 2019)

To access Dr. Kaplan’s narrated deck, click here: http://bit.ly/ProMIS110719 .

To learn more about the role of amyloid beta in Alzheimer’s disease including evidence implicating the toxic oligomer, tune into Saving Minds, at iTunes or Spotify.

About ProMIS Neurosciences
ProMIS Neurosciences, Inc. is a development stage biotechnology company focused on discovering and developing antibody therapeutics selectively targeting toxic oligomers implicated in the development and progression of neurodegenerative diseases, in particular Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD). The Company’s proprietary target discovery platform is based on the use of two complementary thermodynamic, computational discovery engines – ProMIS and Collective Coordinates – to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this unique precision approach, the Company is developing novel antibody therapeutics for AD, ALS and PD. ProMIS is headquartered in Toronto, Ontario, with offices in Cambridge, Massachusetts. ProMIS is listed on the Toronto Stock Exchange under the symbol PMN, and on the OTCQB Venture Market under the symbol ARFXF.

Visit us at www.promisneurosciences.com, follow us on Twitter and LinkedIn

For media inquiries, please contact:
Shanti Skiffington
shanti.skiffington@gmail.com
Tel. 617 921-0808

For Investor Relations please contact:
Alpine Equity Advisors
Nicholas Rigopulos, President
nick@alpineequityadv.com
Tel. 617 901-0785

The TSX has not reviewed and does not accept responsibility for the adequacy or accuracy of this release. This information release contains certain forward-looking information. Such information involves known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements to be materially different from those implied by statements herein, and therefore these statements should not be read as guarantees of future performance or results. All forward-looking statements are based on the Company's current beliefs as well as assumptions made by and information currently available to it as well as other factors. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. Due to risks and uncertainties, including the risks and uncertainties identified by the Company in its public securities filings, actual events may differ materially from current expectations. The Company disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

About GlobeNewswire

GlobeNewswire
GlobeNewswire
One Liberty Plaza - 165 Broadway
NY 10006 New York

https://globenewswire.com

GlobeNewswire is one of the world's largest newswire distribution networks, specializing in the delivery of corporate press releases financial disclosures and multimedia content to the media, investment community, individual investors and the general public.

Subscribe to releases from GlobeNewswire

Subscribe to all the latest releases from GlobeNewswire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from GlobeNewswire

Leasinvest Real Estate SCA: 2019 Bond Private Placement20.11.2019 19:30:00 CETPress release

Bond private placement for an amount of EUR 100 million Leasinvest Real Estate SCA today successfully issued a 7-year private placement of bonds amounting to EUR 100 million, in denominations of EUR 100,000. The bonds offer a fixed annual coupon of 1.95% and have been placed with investors in Belgium, France and Luxembourg. BNP Paribas Fortis and Degroof Petercam were appointed as Global Coordinators of the transaction. BNP Paribas Fortis, Degroof Petercam and KBC acted as Joint Bookrunners of the transaction. The placement fits within Leasinvest Real Estate’s strategy to arrange financing sources best suited to carry out its investment strategy both through acquisitions and redevelopment of existing core assets. The proceeds will, amongst other things, serve to refinance the EUR 75 million public bond which matured on 9 October 2019 and will contribute to an increase of the average duration of the total debt of Leasinvest Real Estate and a diversification of its financing sources. MIC

IMCD expands Americas footprint by acquiring Colombian specialty distributor Unired Químicas20.11.2019 19:00:00 CETPress release

ROTTERDAM, The Netherlands (20 November 2019) – IMCD N.V. (“IMCD” or “Company”), a leading distributor of specialty chemicals and food ingredients, today announced that it has acquired 100% of the outstanding shares of the Colombia-based ingredient distributor, Unired Químicas SAS (“Unired”). With an office in Bogota, Colombia, Unired distributes specialty chemicals and ingredients to the pharmaceutical, food and personal care markets. In 2018, Unired generated a revenue of USD 8 million and has approximately 15 employees. The company will be fully integrated with IMCD’s organisation in 2020. Please find attached the full press release. Attachment PRESS RELEASE_IMCD expands Americas footprint by acquiring Colombian specialty distributor Unired Químicas

Agfa-Gevaert: Publication of a transparency notification (Axxioon) – Regulated information20.11.2019 17:40:00 CETPress release

(Article 14 of the law of May 2, 2007 on the disclosure of significant shareholdings) Mortsel, Belgium – November 20, 2019 – 5.40 p.m. CET According to Agfa-Gevaert NV’s bylaws, the threshold as from which a shareholding needs to be disclosed, has been set at 3%, 5% and a multiple of 5%. In conformity with the Law of May 2, 2007 regarding the disclosure of significant shareholdings in listed companies, Agfa-Gevaert (Euronext: AGFB) discloses the following declaration: On November 19, 2019, Axxion S.A. has announced that as per November 15, 2019, it holds a stake in Agfa-Gevaert of 5,598,000 shares or 3.26% (denominator is 171,851,042), thus crossing the 3% threshold upwards. Notifications of important shareholdings to be made according to the Law of May 2, 2007 or Agfa-Gevaert NV’s bylaws, should be sent to viviane.dictus@agfa.com. About Agfa The Agfa-Gevaert Group develops, manufactures and distributes an extensive range of analogue and digital imaging systems and IT solutions, mainly

Notice on Convocation of Extraordinary General Meeting of Shareholders of AB Klaipedos nafta20.11.2019 15:02:00 CETPress release

Notice is hereby given that on the initiative and by the resolution of the Board of AB Klaipedos Nafta, legal entity code 110648893, with the registered office at Burių str. 19, Klaipeda (hereinafter - the Company), Extraordinary General Meeting of Shareholders of the Company will be held on 12 December 2019 at 1:00 p.m. The meeting will be held in the Company’s office at Buriu str. 19, Klaipeda, in the administrative office of the Company (in the hall of the meeting on the 2nd floor). Agenda of the meeting: Regarding the approval of the additional decision of the Board of AB Klaipėdos nafta to pledge from 2025 all current and future amounts receivable (the Security Component) of the Company for the benefit of the Ministry of Finance of the Republic of Lithuania for the state guarantee granted by the Republic of Lithuania; Regarding the approval of the additional decision of the Board of AB Klaipėdos nafta to obtain and present up to EUR 20,000,000 (twenty million euros) annual bank gu

 Åland Index Solutions - a game changer tackling climate crisis at every transaction20.11.2019 14:10:00 CETPress release

Ålandsbanken Abp Pressrelease 20.11.2019 Åland Index Solutions - a game changer tackling climate crisis at every transaction Åland Index Solutions, a joint venture between Doconomy and Ålandsbanken, enables banks, payment providers and financial institutions to offer all customers transaction based impact calculations. Åland Index is the global index solution for CO2 emission calculations that guide consumers in their everyday consumption towards more sustainable choices. “With Åland Index Solutions we can engage all financial players in the fight against climate change. This collaboration is a milestone in creating a global standard for measuring the impact of consumption and totally changing the way we consume through connecting spending patterns with climate impact, says Nathalie Green CEO at Doconomy” The original Åland Index was developed in 2016 and the team has ever since been working to help consumers become aware of their impact on the planet. Åland Index is continuously being

Åland Index Solutions – en avgörande skillnad för banker som vill angripa klimatkrisen i varje transaktion20.11.2019 14:10:00 CETPressemelding

Ålandsbanken Abp Pressmeddelande 20.11.2019 Åland Index Solutions – en avgörande skillnad för banker som vill angripa klimatkrisen i varje transaktion Åland Index Solutions, ett samägt bolag mellan Doconomy och Ålandsbanken, skapar förutsättningar för banker, företag som erbjuder betaltjänster och finansiella institutioner att erbjuda sina kunder transaktionsbaserade påverkansberäkningar. Åland Index är det globala index för beräkningar av koldioxidutsläpp som hjälper individer ställa om sin konsumtion till att bli mer klimatmässigt uthållig. ”Med Åland Index Solutions kan vi aktivera alla finansiella aktörer i kampen mot klimatförändringarna. Samarbetet är en milstolpe i skapandet av en global standard för att mäta konsumtionens klimatpåverkan och genom att koppla samman konsumtionsmönster med påverkan, i grunden, förändra det sätt vi konsumerar på”, säger Nathalie Green, vd på Doconomy. Åland Index lanserades 2016 och utvecklingsteamet har sedan dess arbetat med att hjälpa konsumente