GlobeNewswire

Karolinska Development’s portfolio company Aprea Therapeutics lead candidate drug eprenetapopt reaches primary efficacy endpoint in combination therapy of acute myeloid leukemia

Share

STOCKHOLM, SWEDEN – June 17, 2021. Karolinska Development AB (Nasdaq Stockholm: KDEV) announces today that its portfolio company Aprea Therapeutics has reported positive outcomes in an ongoing Phase 1/2 study evaluating the efficacy of the company’s candidate drug eprenetapopt in combination with venteoclax and azacitidine in patients treated for TP53 mutated acute myeloid leukemia, AML. The results show that the primary efficacy endpoint of complete remission was reached in 37% of patients.

The results are underpinned by an analysis performed on 30 evaluable patients, demonstrating complete remission in 37% of the cases. the composite response rate, i.e. CR combined with CR with incomplete hematologic recovery (CRi), CR/CRi, was 53%. The pre-defined primary efficacy endpoint concerning complete remission was thus reached in accordance with the applied study design (Simon’s 2-stage). Eleven patients remain on the study treatment and is continuously monitored on safety and efficacy parameters. Aprea Therapeutics will discuss the dataset with the U.S Food and Drug Agency (FDA) in the second half of 2021 and expects to present the study results at future scientific and medical conferences

Eprenetapopt is a small-molecular drug candidate that targets the tumor inhibitory protein p53 and reactivates its activity. Mutations in the p53 gene occur in approximately 50% of all human tumors and are associated with poor overall disease survival. The drug candidate is currently undergoing clinical studies as a potential treatment for hematological malignancies and solid tumors.

“We are positive to the recent data presented in Aprea Therapeutics’ Phase 1/2 study showing clinical efficacy of eprenetapopt in a difficult-to-treat group of the patient population. As the study finishes and the final results are presented, we look forward to evaluating the data and the continued efforts toward more efficient treatments of severe forms of cancer,” comments Karolinska Development's CEO, Viktor Drvota.

Karolinska Development has an interest in Aprea Therapeutics through KDev Investment amounting to a total holding of 8.4% of the outstanding shares in Aprea Therapeutics.

For further information, please contact:

Viktor Drvota, CEO, Karolinska Development AB
Phone: +46 73 982 52 02, e-mail: viktor.drvota@karolinskadevelopment.com

Johan Dighed, General Counsel and Deputy CEO, Karolinska Development AB
Phone: +46 70 207 48 26, e-mail: johan.dighed@karolinskadevelopment.com

TO THE EDITORS

About Karolinska Development AB

Karolinska Development AB (Nasdaq Stockholm: KDEV) is a Nordic life sciences investment company. The company focuses on identifying breakthrough medical innovations in the Nordic region that are developed by entrepreneurs and leadership teams. The Company invests in the creation and growth of companies that advance these assets into commercial products that are designed to make a difference to patients' lives while providing an attractive return on investment to shareholders.

Karolinska Development has access to world-class medical innovations at the Karolinska Institutet and other leading universities and research institutes in the Nordic region. The Company aims to build companies around scientists who are leaders in their fields, supported by experienced management teams and advisers, and co-funded by specialist international investors, to provide the greatest chance of success.

Karolinska Development has a portfolio of ten companies targeting opportunities in innovative treatment for life-threatening or serious debilitating diseases.

The Company is led by an entrepreneurial team of investment professionals with a proven track record as company builders and with access to a strong global network.

For more information, please visit www.karolinskadevelopment.com.

Attachment

To view this piece of content from www.globenewswire.com, please give your consent at the top of this page.
To view this piece of content from ml-eu.globenewswire.com, please give your consent at the top of this page.

About GlobeNewswire

GlobeNewswire
GlobeNewswire
One Liberty Plaza - 165 Broadway
NY 10006 New York

https://globenewswire.com

GlobeNewswire is one of the world's largest newswire distribution networks, specializing in the delivery of corporate press releases financial disclosures and multimedia content to the media, investment community, individual investors and the general public.

Subscribe to releases from GlobeNewswire

Subscribe to all the latest releases from GlobeNewswire by registering your e-mail address below. You can unsubscribe at any time.

Latest releases from GlobeNewswire

Boyden Welcomes Healthcare & Life Sciences Expert Stephen Irish as Managing Partner, Japan4.8.2021 20:00:00 CEST | Press release

Long-term specialist in senior-level recruitment in Japan and Asia/Pacific joins Boyden as head of the Japan office and member of Boyden’s global healthcare & life sciences practice TOKYO, Aug. 04, 2021 (GLOBE NEWSWIRE) -- Boyden, a premier leadership and talent advisory firm with more than 75 offices in over 45 countries, is delighted to welcome Stephen Irish as Managing Partner and head of Boyden Japan. Based in Tokyo, Irish joins Boyden’s global healthcare & life sciences practice, leading senior level searches for clients in Japan and Asia/Pacific, as well as those headquartered outside the region. “Japan is a unique market, and requires specialist knowledge and understanding of the cultural nuances at the individual, organisational and government level,” commented Stephen Irish, Managing Partner, Boyden Japan. “Having worked with Japanese companies throughout my career, I am delighted to bring this experience into a collaborative, international environment with Boyden. For clients

Novo Nordisk's net profit increased by 10% in the first six months of 20214.8.2021 16:41:41 CEST | Press release

4 August 2021 - Financial report for the period 1 January 2021 to 30 June 2021 Operating profit decreased by 1% in Danish kroner and increased by 9% at constant exchange rates (CER).Sales increased by 5% in Danish kroner and by 12% at CER to DKK 66.8 billion. Sales in International Operations increased by 7% in Danish kroner (13% at CER), and sales in North America Operations increased by 1% in Danish kroner (11% at CER).Sales within Diabetes and Obesity care increased by 5% in Danish kroner to DKK 56.9 billion (13% at CER), driven by GLP-1 growth of 21% in Danish kroner (30% at CER) reflecting the uptake of Ozempic® and Rybelsus®. Obesity care grew by 23% in Danish kroner (34% at CER) and Biopharm sales remained unchanged in Danish kroner (increased by 7% at CER).In June 2021, Wegovy™, semaglutide 2.4 mg, was made available to patients in the US following the approval from the US Food and Drug Administration (FDA) for weight management in adults living with obesity.For the 2021 outloo

Novo Nordisk's net profit increased by 10% in the first six months of 20214.8.2021 16:23:58 CEST | Press release

4 August 2021 - Financial report for the period 1 January 2021 to 30 June 2021 Operating profit decreased by 1% in Danish kroner and increased by 9% at constant exchange rates (CER).Sales increased by 5% in Danish kroner and by 12% at CER to DKK 66.8 billion. Sales in International Operations increased by 7% in Danish kroner (13% at CER), and sales in North America Operations increased by 1% in Danish kroner (11% at CER).Sales within Diabetes and Obesity care increased by 5% in Danish kroner to DKK 56.9 billion (13% at CER), driven by GLP-1 growth of 21% in Danish kroner (30% at CER) reflecting the uptake of Ozempic® and Rybelsus®. Obesity care grew by 23% in Danish kroner (34% at CER) and Biopharm sales remained unchanged in Danish kroner (increased by 7% at CER).In June 2021, Wegovy™, semaglutide 2.4 mg, was made available to patients in the US following the approval from the US Food and Drug Administration (FDA) for weight management in adults living with obesity.For the 2021 outloo

Nexstim to Exhibit at the Texas Association of Neurological Surgeons Annual Meeting4.8.2021 15:00:00 CEST | Press release

Press release, Helsinki, 4 August 2021 at 4 PM(EEST) Nexstim to Exhibit at the Texas Association of Neurological Surgeons Annual Meeting Nexstim Plc (NXTMH:HEX, NXTMS:STO) ("Nexstim" or "Company") announces that it will be exhibiting during the annual meeting of the Texas Association of Neurological Surgeons this week, August 5-8, 2021 at the Hyatt Regency Lost Pines Resort & Spa in Lost Pines, Texas. This meeting continues to be a significant opportunity for Nexstim to engage current and prospective users of the Nexstim system. Further information is available on the website www.nexstim.com, or by contacting: Mikko Karvinen, CEO +358 50 326 4101 mikko.karvinen@nexstim.com About Nexstim Plc Nexstim is a Finnish, globally operating medical technology company. Our mission is to enable personalized and effective therapies and diagnostics for challenging brain diseases and disorders. Nexstim has developed a world-leading non-invasive brain stimulation technology called SmartFocus®. It is a

ProMIS Neurosciences Issues Chairman’s Memorandum4.8.2021 13:30:00 CEST | Press release

Notes and comments after the first AAIC meeting in the era of approved disease-modifying therapies for Alzheimer’s Disease TORONTO and CAMBRIDGE, Mass., Aug. 04, 2021 (GLOBE NEWSWIRE) -- ProMIS Neurosciences, Inc. (TSX: PMN) (OTCQB: ARFXF), a biotechnology company focused on the discovery and development of antibody therapeutics targeting toxic oligomers implicated in the development of neurodegenerative diseases, issued today a Chairman’s memorandum, commenting on highlights of the recent 2021 Alzheimer’s Association International Conference (AAIC) with relevance to ProMIS and summarizing the ProMIS poster/oral presentation contributions to the meeting. “We are in a new era in the fight against Alzheimer’s, ALS, and other neurodegenerative diseases,” stated Eugene Williams, Executive Chairman of ProMIS Neurosciences. “ProMIS and many others have predicted this development and we believe that the Alzheimer’s community will look back on 2021 as a turning point, just as 2010 was a turnin

Aspo Plc will publish its Half year financial report on August 11, 20214.8.2021 12:00:00 CEST | Press release

Aspo Plc Press Release August 4, 2021 at 1 p.m. Aspo Plc will publish its Half year financial report on August 11, 2021 Aspo Plc will publish its Half year financial report for January–June 2021 on Wednesday, August 11, 2021 at approximately 9:30 a.m. EEST. The press conference for analysts, investors and media will be held on Wednesday, August 11, 2021 at 2 p.m. The Half year financial report will be presented by CEO Aki Ojanen. The press conference will be held in Finnish and it can be followed at https://aspo.videosync.fi/2021-q2-results, or by calling +358 9 817 10310 (12219443#) 5 to 10 minutes before the beginning of the press conference. The recording of the event will be available on the company’s website later on the same day. Presentation material will be available at www.aspo.com before the event. Aspo Plc Aki Ojanen CEO For further information, please contact: Keijo Keränen, Group Treasurer, +358 400 955 821, keijo.keranen@aspo.com DISTRIBUTION: Key media www.aspo.com Aspo

Cortus Energy: Sista dag för handel med betalda tecknade units (BTU) och omvandling till aktier och teckningsoptioner av serie TO8 och TO94.8.2021 09:46:34 CEST | Pressemelding

PRESSMEDDELANDE Stockholm, den 4 augusti 2021 Cortus Energy AB (”Cortus Energy” eller ”Bolaget”) har som tidigare kommunicerats genomfört en övertecknad företrädesemission av units om cirka 64,8 MSEK ("Företrädesemissionen"). Företrädesemissionen är nu registrerad hos Bolagsverket ochsista dag för handel med BTU är fredagenden 6augusti 2021. Avstämningsdag för omvandlingen är den 10augusti 2021, varefter BTU kommer att omvandlas till aktier och teckningsoptioner av serie TO8 och TO9. Aktier och teckningsoptioner som tecknades i Företrädesemissionen förväntas vara tillgängliga på tecknarens depå/vp-konto den 12 augusti 2021. Första handelsdag för teckningsoptionerna i serie TO8 och TO9 förväntas vara den 13 augusti 2021. Teckningsoptioner av serie TO8 Teckning av aktier med stöd av teckningsoptioner av serie TO8 sker under perioden från och med den 16 november 2021 till och med den 29 november 2021. Varje teckningsoption av serie TO8 ger rätt att teckna en (1) ny aktie i Bolaget mot kon