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Biotalys and Olon Enter into Long-Term Partnership for the Production of Protein-Based Biocontrols

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Major step forward in terms of production efficiency and scalability

Ghent, BELGIUM, and Milan, ITALY, Jan. 12, 2022 (GLOBE NEWSWIRE) -- Press release

Biotalys and Olon Enter into Long-Term Partnership forthe Productionof Protein-Based Biocontrols

Relying on its leading expertise in microbial fermentation, Olon Group will manufactureBiotalysbiocontrols beginning with Evoca

Major step forward in terms of production efficiencyand scalability

Ghent, BELGIUM,and Milan, ITALY12 January 2022, 07:00 CETBiotalys (Euronext - BTLS), an Agricultural Technology (AgTech) company protecting crops and food with protein-based biocontrol solutions, and Olon, a world-leading contract development and manufacturing organization, today announced a long-term strategic partnership for the manufacturing of Biotalys’ biocontrol products. The partnership is driven by the common vision of transforming food protection with unique protein-based biocontrol solutions and secures the global supply of Biotalys’ newly developed biofungicide, Evoca™*, planned for market introduction in the United States in the second half of 2022 – pending regulatory approval.

Evoca, the first protein-based biocontrol in the Biotalys pipeline, aims to provide fruit and vegetable growers with a new rotation partner in integrated pest management (IPM) programs. It helps control diseases such as Botrytis and powdery mildew, thus reducing the dependency on chemical pesticides with corresponding residues in harvested produce while offering a distinctive new tool to manage pathogen resistance development.

Under the partnership, Olon will produce the active ingredient of Evoca at its world-class biotech manufacturing sites in Capua and Settimo Torinese (Italy), two centers of excellence in the microbial fermentation field meeting the highest quality standards. Relying on experience gained over more than 50 years, Olon’s expertise includes extensive know-how of microbial fermentation, one of the most eco-friendly and sustainable technologies capable of significantly reducing the overall environmental impact.

In Capua, Olon’s fermentation facility operates a range of bioreactors of up to 35m³, while the facility in Settimo Torinese envisages production in batches of up to 112m³ – far above the capacity reached until now for Biotalys’ products. This upscaling therefore signifies a major step forward in terms of production efficiency and scalability of protein-based biocontrols. Olon will both handle the fermentation process of the products developed by Biotalys in its laboratories in Ghent and purify them into the technical intermediate which will then be formulated by an external provider to create the end products.

“Biotalys’ protein-based biocontrols are a promising new class of products to help growers protect their crops in an environmentally sustainable way,” saidPaolo Tubertini, CEO of Olon. “They perfectly match with our long-term plan that focuses on novel biotech solutions and, consequently, the expansion of our capacity to support innovative biotech companies to accelerate the development of new products in a more sustainable way. According to this strategy we offer one of the biggest platforms of microbial fermentation production globally. It means the application of sustainable biotechnology to industrialization.”

Patrice Sellès, CEO of Biotalys, stated: "Olon is a world leader in the sustainable production of proteins, so we are very excited to partner with them for the manufacturing of our protein-based solutions, beginning with our first biofungicide Evoca. With its state-of-the-art manufacturing facilities and processes, Olon will be able to provide us with the quantity of product we need for the planned market calibration, while ensuring it meets all regulatory, quality and safety specifications. Upon formulation, the end product will give growers a new tool to use in integrated pest management programs to fight devastating fungal diseases in many fruits and vegetables.”

Biotalys submitted Evoca for registration to the Environmental Protection Agency (EPA) in the United States in December 2020. Following the submission, Biotalys passed both the provided completeness check and the preliminary technical screening. The company expects to receive EPA approval in H2 2022. Biotalys also submitted for approval in California in April 2021, as this State performs its own in-depth review. In the European Union, Biotalys received confirmation from the European Food Safety Authority (EFSA) and the College for approval of crop protection products and biocides (Ctgb) that the registration dossier submitted in March 2021 for the active substance of Evoca is admissible for review.

* Evoca™: Pending Registration. This product is not currently registered for sale or use in the United States, the European Union,or elsewhere and is not being offered for sale.

About Biotalys

Biotalys is an Agricultural Technology (AgTech) company protecting crops and food with proprietary protein-based biocontrol solutions and aiming to provide alternatives to conventional chemical pesticides for a more sustainable and safer food supply. Based on its novel AGROBODY™ technology platform, Biotalys is developing a strong and diverse pipeline of effective product candidates with a favorable safety profile that aim to address key crop pests and diseases across the whole value chain, from soil to plate. Biotalys was founded in 2013 as a spin-off from the VIB (Flanders Institute for Biotechnology) and is listed on Euronext Brussels since July 2021. The company is based in the biotech cluster in Ghent, Belgium. More information can be found on www.biotalys.com.

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About Olon

With a 2020’s turnover of USD 530 Mio, Olon supplies 34 Chemical Intermediates and more than 295 APIs for markets as pharma, food and agriculture. Thanks to all the 2,200 employees, and to a highly qualified R&D team of more than 200 people, Olon can offer complete integrated packages and services to support the full development of APIs based on strong knowledge in both chemical and biological processes, all of them under a full cGMP and regulatory coverage. Headquartered in Rodano (Milan, Italy), Olon has 11 manufacturing facilities – 8 located in Italy, 1 in Spain, 1 in USA and 1 in India, designed in compliance with the strictest international requirements – and 3 branch offices in Hamburg (Germany), Florham Park NJ (USA) and Shanghai (China). The group has recently launched “Innovation Initiatives”: an internal program to explore new technologies or new applications for existing technologies, with a big focus on biotech.

www.olonspa.com

For further information, please contact

For Biotalys:

Toon Musschoot, Head of IR & Communication

Telephone: +32 (0)9 274 54 00

Email: Toon.Musschoot@biotalys.com

For Olon:

Sabrina Spina

Mobile: +39 338 6674289

Email: sspina@olonspa.it

Important Notice

This announcement contains statements which are "forward-looking statements" or could be considered as such. These forward-looking statements can be identified by the use of forward-looking terminology, including the words ‘aim’, 'believe', 'estimate', 'anticipate', 'expect', 'intend', 'may', 'will', 'plan', 'continue', 'ongoing', 'possible', 'predict', 'plans', 'target', 'seek', 'would' or 'should', and contain statements made by the company regarding the intended results of its strategy. By their nature, forward-looking statements involve risks and uncertainties and readers are warned that none of these forward-looking statements offers any guarantee of future performance. The Biotalys actual results may differ materially from those predicted by the forward-looking statements. Biotalys makes no undertaking whatsoever to publish updates or adjustments to these forward-looking statements, unless required to do so by law.

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