Oxurion Receives Transparency Notifications Based on New Denominator

Leuven, BELGIUM, Boston, MA, US –November 17, 2022 –8 AM CETOxurion NV (Euronext Brussels: OXUR) a biopharmaceutical company developing next generation standard of care ophthalmic therapies, with clinical stage assets in vascular retinal disorders, today announced that, pursuant to Belgian Transparency legislation¹ it has received transparency notifications as follows:

Following the issuance of new shares pursuant to the Capital Commitment entered into with Negma Group Ltd., the updated denominator for transparency notifications was 109,075,765 shares as of November 11, 2022: Information on the Total Number of Voting Rights (Denominator) following Conversion Notice from NEGMA | Oxurion NV)

Oxurion received transparency notification from Negma Group indicating that as of November 16, it holds 0 common shares. Oxurion also received transparency notification from Fidelity Management & Research Company LLC that their 3,128,819 common shares have crossed below the lowest threshold (3%) by virtue of a downward passive crossing.

In addition, by virtue of a downward passive crossing, the following thresholds have been crossed:

• Novartis Pharma AG’s 2,177,226 shares have crossed below the lowest threshold (3%)
• Philippe Vlerick/Balderma SA’s 3,580,787 shares have crossed below the lowest threshold (3%)
• Thomas M. Clay’s 4,542,110 shares have crossed below the 5% threshold
  
  

Content of the latest Negma Group Ltd. Notification

Reason of the notification

Acquisition or disposal of voting securities or voting rights

Notifications by

A person that notifies alone

Threshold that is crossed

Downward crossing of the lowest threshold

Denominator

109,075,765

Chain of controlled undertakings through which the holding is effectively held

Not applicable

Notified details

See Annex 1 for this and prior transparency notification of November

Content of the Fidelity Management & Research Company LLC Notification

Reason of the notification

Passive crossing of a threshold
Downward crossing of the lowest threshold

Notifications by

A parent undertaking or a controlling person

Threshold that is crossed

3%

Denominator

109,075,765

Notified details

See Annex 2

Chain of controlled undertakings through which the holding is effectively held

Fidelity Management & Research Company LLC is controlled by FMR LLC.

FMR LLC is not a controlled entity

About Oxurion

Oxurion (Euronext Brussels: OXUR) is a biopharmaceutical company developing next generation standard of care ophthalmic therapies, which are designed to improve and better preserve vision in patients with retinal disorders including diabetic macular edema (DME), the leading cause of vision loss in working-age people, as well as other conditions. Oxurion intends to play an important role in the treatment of retinal disorders, including the successful development of THR-149, its novel therapeutic for the treatment of DME. THR-149 is a potent plasma kallikrein inhibitor being developed as a potential new standard of care for the up to 50% of DME patients showing suboptimal response to anti-VEGF therapy. Oxurion is headquartered in Leuven, Belgium, with corporate operations in Boston, MA. More information is available at www.oxurion.com.

Important information about forward-looking statements

Certain statements in this press release may be considered “forward-looking”. Such forward-looking statements are based on current expectations, and, accordingly, entail and are influenced by various risks and uncertainties. The Company therefore cannot provide any assurance that such forward-looking statements will materialize and does not assume any obligation to update or revise any forward-looking statement, whether as a result of new information, future events, or any other reason. Additional information concerning risks and uncertainties affecting the business and other factors that could cause actual results to differ materially from any forward-looking statement is contained in the Company’s Annual Report. This press release does not constitute an offer or invitation for the sale or purchase of securities or assets of Oxurion in any jurisdiction. No securities of Oxurion may be offered or sold within the United States without registration under the U.S. Securities Act of 1933, as amended, or in compliance with an exemption therefrom, and in accordance with any applicable U.S. state securities laws.

For further information please contact:

Oxurion NV Tom Graney Chief Executive Officer Tel: +32 16 75 13 10 tom.graney@oxurion.com Michael Dillen Chief Business Officer Tel: +32 16 75 13 10 michael.dillen@oxurion.com

US Conway Communications Beth Kurth bkurth@conwaycommsir.com ICR Westwicke Christopher Brinzey Tel: +1 617 835 9304 Chris.Brinzey@westwicke.com

ANNEX 1

Negma notification of November 16, 2022

A)Votingrights	Previousnotification	Afterthetransaction
	#ofvotingrights	#ofvotingrights		%ofvotingrights
Holders of voting rights		Linked to securities	Not linked to the securities	Linked to securities	Not linked to the securities
Elaf Gassam	0	0					-
Negma Group Investment Ltd.	0	0					-
Negma Group Ltd.	16,250,000	0					-
Subtotal	16,250,000	0					+

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B)Equivalentfinancialinstruments	Afterthetransaction
Holdersofequivalentfinancialinstruments	Typeoffinancialinstrument	Expirationdate	Exerciseperiodordate	#ofvotingrightsthat may beacquired if theinstrumentisexercised	%ofvotingrights	Settlement
							+
TOTAL				0	0.00%

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TOTAL(A& B)		#ofvotingrights	%ofvotingrights
	CALCULATE	0	0.00%

Negma notification of November 8, 2022

A)Votingrights	Previousnotification	Afterthetransaction
	#ofvotingrights	#ofvotingrights		%ofvotingrights
Holders of voting rights		Linked to securities	Not linked to the securities	Linked to securities	Not linked to the securities
02/11/2022: Negma Group Ltd. Threshold: + 15 %	0	15,000,000		16.16%			-
03/11/2022: Negma Group Ltd. Threshold: - 10 %		8,828,255					-
04/11/2022: Negma Group Ltd		8,750,000					-
7/11/2022: Negma Group Ltd. Threshold: - 3 % (see section 13)		0					-
Subtotal		15,000,000		16.16%			+
TOTAL		15,000,000	0	16.16%	0.00%

B)Equivalentfinancialinstruments	Afterthetransaction
Holdersofequivalentfinancialinstruments	Typeoffinancialinstrument	Expirationdate	Exerciseperiodordate	#ofvotingrightsthat may beacquired if theinstrumentisexercised	%ofvotingrights	Settlement
							+
TOTAL				0	0.00%

TOTAL(A& B)		#ofvotingrights	%ofvotingrights
	CALCULATE	15,000,000	16.16%

ANNEX 2

B)Equivalentfinancialinstruments	Afterthetransaction
Holdersofequivalentfinancialinstruments	Typeoffinancialinstrument	Expirationdate	Exerciseperiodordate	#ofvotingrightsthat may beacquired if theinstrumentisexercised	%ofvotingrights	Settlement
Fidelity Management & Research Company LLC	Stock Loan			90,401	0.08%	physical	+
TOTAL				90,401	0.08%

TOTAL(A&B)		#ofvotingrights	%ofvotingrights
	CALCULATE	3,128,819	2.87%

________

1. Article 14, first paragraph, of the Law of 2 May 2007 on disclosure of major holdings.

Attachment

• OXUR Transparency Notifications (EN) 2022.1117

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